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Articles Published Processes
8/11/2023 11:04:23 AM | Browse: 186 | Download: 564
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Received |
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2023-02-27 19:46 |
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Peer-Review Started |
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2023-02-27 19:49 |
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To Make the First Decision |
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Return for Revision |
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2023-04-11 06:41 |
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Revised |
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2023-04-24 12:14 |
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Second Decision |
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2023-05-16 03:04 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-05-16 23:02 |
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Articles in Press |
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2023-05-16 23:02 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-05-23 09:44 |
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Typeset the Manuscript |
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2023-08-05 06:11 |
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Publish the Manuscript Online |
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2023-08-11 11:04 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Prognostic role of metformin in diabetes mellitus type 2 patients with hepatocellular carcinoma: A systematic review and meta-analysis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Maja Cigrovski Berkovic, Francesco Giovanardi, Anna Mrzljak and Quirino Lai |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Maja Cigrovski Berkovic, MD, PhD, Adjunct Associate Professor, Department of Kinesiological Anthropology and Methodology, Faculty of Kinesiology, University of Zagreb, Horvaćanski zavoj 15, Zagreb 10000, Croatia. maja.cigrovskiberkovic@gmail.com |
| Key Words |
Hepatocellular carcinoma; Metformin; Type 2 diabetes mellitus; Death; Recurrence; Progression; Treatment |
| Core Tip |
The identification of chemopreventive agents following hepatocellular carcinoma (HCC) treatments with potential to lower the risk of its adverse course is of paramount relevance. Among them, metformin has been recently explored in this setting. The present systematic review and meta-analysis aim to explore the role of metformin in preventing HCC adverse events (i.e., death, tumor progression, and recurrence). Metformin only merged statistical relevance as a protective factor for the risk of death in case of patients receiving curative therapies for HCC, while failed as a protective agent for progressive disease and recurrence. Further large experiences are required for definitively clarifying the real impact of metformin as chemopreventive agent for HCC. |
| Publish Date |
2023-08-11 11:04 |
| Citation |
Cigrovski Berkovic M, Giovanardi F, Mrzljak A, Lai Q. Prognostic role of metformin in diabetes mellitus type 2 patients with hepatocellular carcinoma: A systematic review and meta-analysis. World J Diabetes 2023; 14(8): 1289-1300 |
| URL |
https://www.wjgnet.com/1948-9358/full/v14/i8/1289.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i8.1289 |
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