Publication Name	World Journal of Pharmacology
Manuscript ID	84146
Country	Brazil

Received	2023-03-02 20:04
Peer-Review Started	2023-03-01 18:46
To Make the First Decision
Return for Revision	2023-04-13 08:16
Revised	2023-05-05 21:42
Second Decision	2023-05-31 03:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-05-31 07:59
Articles in Press	2023-05-31 07:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-06-14 01:45
Publish the Manuscript Online	2023-06-15 08:11

ISSN	2220-3192 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	In silico insight into Amurensinine - an N-Methyl-D-Aspartate receptor antagonist
Manuscript Source	Unsolicited Manuscript
All Author List	Cinthia Façanha Wendel, Queren Hapuque Oliveira Alencar, Rafaela Viana Vieira and Kádima Nayara Teixeira
ORCID	Author(s) ORCID Number Cinthia Façanha Wendel http://orcid.org/0000-0003-2183-9748 Queren Hapuque Oliveira Alencar http://orcid.org/0000-0002-3282-0113 Rafaela Viana Vieira http://orcid.org/0000-0002-2725-9886 Kádima Nayara Teixeira http://orcid.org/0000-0002-2928-9181
Funding Agency and Grant Number
Corresponding Author	Kádima Nayara Teixeira, PhD, Professor, Campus Toledo, Universidade Federal do Paraná, Max Planck 3796, Toledo 85.919-899, Paraná, Brazil. kadimateixeira@ufpr.br
Key Words	Amurensinine; Bioinformatics analysis; Isopavines; Molecular docking; N-methyl-D-Aspartate receptor
Core Tip	Amurensinine binds to a region of the amino terminal domain on the N-methyl-D-Aspartate receptor and the interaction is stabilized mainly by covalent bonds, which confer an affinity energy of significant value to the receptor/Ligand complex. The interaction between Amurensinine and the receptor, which is involved in neurological diseases, suggests that this isopavine may interfere with its function, so it may have therapeutic potential in this area.
Publish Date	2023-06-15 08:11
Citation	Façanha Wendel C, Hapuque Oliveira Alencar Q, Viana Vieira R, Teixeira KN. In silico insight into Amurensinine - an N-Methyl-D-Aspartate receptor antagonist. World J Pharmacol 2023; 12(3): 25-34
URL	https://www.wjgnet.com/2220-3192/full/v12/i3/25.htm
DOI	https://dx.doi.org/10.5497/wjp.v12.i3.25

Full Article (PDF)	WJP-12-25-with-cover.pdf
Full Article (Word)	WJP-12-25.docx
Manuscript File	84146_Auto_Edited-JLW.docx
Answering Reviewers	84146-Answering reviewers.pdf
Audio Core Tip	84146-Audio core tip.ogg
Conflict-of-Interest Disclosure Form	84146-Conflict-of-interest statement.pdf
Copyright License Agreement	84146-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	84146-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	84146-Language certificate.pdf
Peer-review Report	84146-Peer-review(s).pdf
Scientific Misconduct Check	84146-Bing-Li L-2.png
Scientific Editor Work List	84146-Scientific editor work list.pdf
CrossCheck Report	84146-CrossCheck report.pdf
CrossCheck Report	84146-CrossCheck.png