| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Intervention effects and related mechanisms of glycyrrhizic acid on zebrafish with Hirschsprung-associated enterocolitis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ming-Kun Liu, Ying-Jian Chen, Fei Chen, Zhi-Xiong Lin, Zi-Cheng Zhu, Yu Lin, Yi-Fan Fang and Dian-Ming Wu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Joint Funds for the Innovation of Science and Technology, Fujian Province |
2020Y9139 |
| Startup Fund for Scientific Research, Fujian Medical University |
2019QH1141 |
|
| Corresponding Author |
Dian-Ming Wu, BM BCh, Chief Physician, Department of Pediatric Surgery, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, No. 18 Daoshan Road, Gulou District, Fuzhou 350001, Fujian Province, China. wdm2369@126.com |
| Key Words |
Hirschsprung-associated enterocolitis; High mobility group box 1 protein; Toll-like receptor 4; Interleukin-1β; Interleukin-8; Glycyrrhizic acid |
| Core Tip |
As an important late-stage inflammatory mediator, high mobility group box 1 protein (HMGB1) is involved in the occurrence, development and outcome of many chronic inflammatory diseases and autoimmune diseases. Glycyrrhizic acid (GA) is the most widely used HMGB1 inhibitor, which can directly bind to HMGB1 and inhibit its chemotactic and mitotic activity. Here, we constructed a zebrafish Hirschsprung-associated enterocolitis (HAEC) model and used different concentrations of GA for intervention. Through the intervention study, we understood the effects of HMGB1 inhibitors-GA on the phenotype and inflammatory state of HAEC zebrafish, and the study results provided a new reference for the prevention and treatment of HAEC. |
| Publish Date |
2023-07-21 14:21 |
| Citation |
Liu MK, Chen YJ, Chen F, Lin ZX, Zhu ZC, Lin Y, Fang YF, Wu DM. Intervention effects and related mechanisms of glycyrrhizic acid on zebrafish with Hirschsprung-associated enterocolitis. World J Gastrointest Surg 2023; 15(7): 1317-1330 |
| URL |
https://www.wjgnet.com/1948-9366/full/v15/i7/1317.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v15.i7.1317 |
