Publication Name	World Journal of Cardiology
Manuscript ID	8439
Country	United States

Received	2013-12-28 14:19
Peer-Review Started	2013-12-28 18:42
To Make the First Decision	2014-01-15 16:33
Return for Revision	2014-01-20 17:38
Revised	2014-01-30 17:36
Second Decision	2014-04-16 17:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-16 17:26
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-28 09:30
Publish the Manuscript Online	2014-06-20 19:33

ISSN	1949-8462 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Genetics & Heredity
Manuscript Type	Autobiography
Article Title	Elevated blood pressure: Our family’s fault? The genetics of essential hypertension
Manuscript Source	Invited Manuscript
All Author List	Aniket Natekar, Randi L Olds, Meghann W Lau, Kathleen Min, Karra Imoto and Thomas P Slavin
Funding Agency and Grant Number
Corresponding Author	Thomas P Slavin, MD, Assistant Professor of Pediatrics, The John A Burns School of Medicine, University of Hawaii, 1441 Kapiolani Blvd, Suite 1800, Honolulu, HI 96813, United States. thomas.slavin@kapiolani.org
Key Words	Essential hypertension; Epigenomics; Genome-wide association study; Genes; MicroRNAs
Core Tip	Essential hypertension (EH) is considered a multifactorial disease, indicating that many genetic, epigenetic, and environmental influences affect the initiation and continuance of the disease. Our goal is to provide an updated report on current genetic aspects possibly affecting EH by elucidating genetic factors’ role in EH. We found 130 genes meeting our inclusion/exclusion criteria. To our knowledge, this is the first review to discuss both genetic and epigenetic factors associated with EH in one article. With emerging technologies, more direct causal relationships between genetic and epigenetic factors with EH will likely be disdiscovered, creating tremendous potential for personalized medicine using pharmacogenomics.
Publish Date	2014-06-20 19:33
Citation	Natekar A, Olds RL, Lau MW, Min K, Imoto K, Slavin TP. Elevated blood pressure: Our family’s fault? The genetics of essential hypertension. World J Cardiol 2014; 6(5): 327-337
URL	http://www.wjgnet.com/1949-8462/full/v6/i5/327.htm
DOI	http://dx.doi.org/10.4330/wjc.v6.i5.327

Full Article (PDF)	WJC-6-327.pdf
Full Article (Word)	WJC-6-327.doc
Manuscript File	8439-Review.doc
Answering Reviewers	8439-Answering reviewers.pdf
Copyright License Agreement	8439-Copyright assignment.pdf
Peer-review Report	8439-Peer reviews.pdf
Scientific Editor Work List	8439-Scientific editor work list.doc