| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Observational Study |
| Article Title |
Glucose metabolism profile recorded by flash glucose monitoring system in patients with hypopituitarism during prednisone replacement
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Min-Min Han, Jia-Xin Zhang, Zi-Ang Liu, Lin-Xin Xu, Tao Bai, Chen-Yu Xiang, Jin Zhang, Dong-Qing Lv, Yan-Fang Liu, Yan-Hong Wei, Bao-Feng Wu, Yi Zhang and Yun-Feng Liu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81770776 |
| The Shanxi Provincial Central Leading Local Science and Technology Development Fund Project |
YDZJSX2022A059 |
| Postgraduate Education Innovation Project of Shanxi Province |
2022Y354 |
| National Natural Science Foundation of China |
81973378 |
| National Natural Science Foundation of China |
82073909 |
|
| Corresponding Author |
Yun-Feng Liu, MD, PhD, Chief Physician, Professor, Department of Endocrinology, First Hospital of Shanxi Medical University, No. 85 Jiefang Nan Road, Taiyuan 030000, Shanxi Province, China. nectarliu@163.com |
| Key Words |
Hypopituitarism; Prednisone; Flash glucose monitoring system; Glucose-target-rate; Glucose variability; Period glucose level |
| Core Tip |
Glucocorticoids (GCs) replacement regimens for patients with hypopituitarism are hard to mimic physiological cortisol rhythms and carry risks of over-treatment, which can have adverse effects on glucose metabolism. We assessed the glucose metabolism profile of patients with hypopituitarism receiving prednisone (Pred) replacement, using a flash glucose monitoring system, to clarify impacts of different GCs preparations and prescriptions on glycometabolism, along with the resultant risks of consequent cardiovascular events. The study showed that Pred replacement disturbed glycometabolic homeostasis in patients with hypopituitarism. A dose of > 5 mg/d Pred caused more adverse effects on glycometabolism than ≤ 5 mg/d, contributing to the higher risks of cardiovascular events. |
| Publish Date |
2023-07-13 08:03 |
| Citation |
Han MM, Zhang JX, Liu ZA, Xu LX, Bai T, Xiang CY, Zhang J, Lv DQ, Liu YF, Wei YH, Wu BF, Zhang Y, Liu YF. Glucose metabolism profile recorded by flash glucose monitoring system in patients with hypopituitarism during prednisone replacement. World J Diabetes 2023; 14(7): 1112-1125 |
| URL |
https://www.wjgnet.com/1948-9358/full/v14/i7/1112.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i7.1112 |
