| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
18β-glycyrrhetinic acid promotes gastric cancer cell autophagy and inhibits proliferation by regulating miR-328-3p/signal transducer and activator of transcription-3
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi Yang, Yi Nan, Yu-Hua Du, Shi-Cong Huang, Dou-Dou Lu, Jun-Fei Zhang, Xia Li, Yan Chen, Lei Zhang and Ling Yuan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ningxia Medical University Project |
XZ2021005 |
| Ningxia Natural Science Foundation |
2022AAC03144, 2022AAC02039 |
| National Natural Science Foundation of China |
82260879 |
|
| Corresponding Author |
Ling Yuan, MD, PhD, Professor, N/A, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China. nxykdx@qq.com |
| Key Words |
Autophagy flow; Cell proliferation; Signal transducer and activator of transcription 3; miR-328-3p; 18β-Glycyrrhetinic acid |
| Core Tip |
18β-glycyrrhetinic acid (18β-GRA) is an important bioactive component of glycyrrhiza liquorice. Our results showed that 18β-GRA up-regulates the expression of miR-328-3p in gastric cancer (GC) cell. Overexpression of miR-328-3p inhibits GC cell proliferation and colony formation, arrests the cell cycle, promotes apoptosis, inhibits subcutaneous tumor formation, and signal transducer and activator of transcription 3 (STAT3) expression. Dual-luciferase reporter assay showed that miR-328-3p could target the regulation of STAT3. The study of monomeric Red Fluorescent Protein-green fluorescent protein-light chain 3 double-labeled adenovirus and western blot indicated that 18β-GRA promotes autophagy flow by promoting autophagosome synthesis. These data suggest that 18β-GRA promotes cell autophagy and inhibits the proliferation of GC cell by regulating miR-328-3p/STAT3. |
| Publish Date |
2023-07-13 08:46 |
| Citation |
Yang Y, Nan Y, Du YH, Huang SC, Lu DD, Zhang JF, Li X, Chen Y, Zhang L, Yuan L. 18β-glycyrrhetinic acid promotes gastric cancer cell autophagy and inhibits proliferation by regulating miR-328-3p/signal transducer and activator of transcription-3. World J Gastroenterol 2023;29(27): 4317-4333 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i27/4317.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i27.4317 |
