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Articles Published Processes
7/12/2023 11:13:16 AM | Browse: 230 | Download: 817
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Received |
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2023-03-26 02:23 |
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Peer-Review Started |
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2023-03-26 02:26 |
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To Make the First Decision |
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Return for Revision |
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2023-04-18 02:57 |
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Revised |
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2023-04-28 23:05 |
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Second Decision |
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2023-05-25 02:53 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-05-25 09:19 |
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Articles in Press |
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2023-05-25 09:19 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-07-04 06:57 |
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Publish the Manuscript Online |
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2023-07-12 11:13 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Control Study |
| Article Title |
Proteomics-based identification of proteins in tumor-derived exosomes as candidate biomarkers for colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ge-Yu-Jia Zhou, Dong-Yan Zhao, Teng-Fei Yin, Qian-Qian Wang, Yuan-Chen Zhou and Shu-Kun Yao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Development Plan for Precision Medicine Research |
2017YFC0910002 |
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| Corresponding Author |
Shu-Kun Yao, Doctor, MD, PhD, Chief Physician, Professor, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com |
| Key Words |
Exosomes; Colorectal cancer; Data-independent acquisition; Parallel reaction monitoring; Biomarker |
| Core Tip |
We innovatively combined high-throughput quantitative proteomics analysis with colorectal cancer (CRC) tissue-originated exosomes. The comprehensive proteomic signature of CRC tissue exosomes was described using data-independent acquisition mass spectrometry, which revealed a mass of differentially expressed exosomal proteins. Six promising exosomal proteins, NHP2, OLFM4, TOP1, SAMP, TAGL and TRIM28, were verified by parallel reaction monitoring analysis and receiver operating characteristic curve analysis. The results indicated that these exosomal proteins could become potential diagnostic markers and effective therapeutic targets for CRC. |
| Publish Date |
2023-07-12 11:13 |
| Citation |
Zhou GYJ, Zhao DY, Yin TF, Wang QQ, Zhou YC, Yao SK. Proteomics-based identification of proteins in tumor-derived exosomes as candidate biomarkers for colorectal cancer. World J Gastrointest Oncol 2023; 15(7): 1227-1240 |
| URL |
https://www.wjgnet.com/1948-5204/full/v15/i7/1227.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i7.1227 |
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