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Articles Published Processes
8/25/2023 7:59:11 AM | Browse: 221 | Download: 566
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Received |
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2023-03-26 08:22 |
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Peer-Review Started |
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2023-03-26 08:25 |
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To Make the First Decision |
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Return for Revision |
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2023-05-17 18:14 |
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Revised |
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2023-05-31 04:50 |
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Second Decision |
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2023-06-29 02:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-07-03 22:57 |
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Articles in Press |
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2023-07-03 22:57 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-08-23 03:45 |
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Publish the Manuscript Online |
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2023-08-25 07:59 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Wnt signaling pathway inhibitor promotes mesenchymal stem cells differentiation into cardiac progenitor cells in vitro and improves cardiomyopathy in vivo
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rabbia Muneer, Rida-e-Maria Qazi, Abiha Fatima, Waqas Ahmad, Asmat Salim, Luciana Dini and Irfan Khan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Irfan Khan, PhD, Assistant Professor, Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, University Road, Karachi 75270, Sindh, Pakistan. khan@iccs.edu |
| Key Words |
Myocardial infarction; Inhibitor Wnt production-4; Differentiation; Mesenchymal stem cells; Wnt pathway; Cardiac function |
| Core Tip |
This study highlights the role of Wnt signaling pathway in the differentiation of mesenchymal stem cells (MSCs) into cardiac progenitor cells and the therapeutic potential of MSCs conditioned with inhibitor Wnt production-4 (IWP-4) for the treatment of heart disease. Further studies are required to comprehend the mode of action of IWP-4 on MSCs and to assess its potency and safety in human clinical trials. Nevertheless, this research is an exciting step forward for new treatments for heart diseases and is more focused on the importance of continued investment in the development of innovative therapies for this devastating condition. |
| Publish Date |
2023-08-25 07:59 |
| Citation |
Muneer R, Qazi R, Fatima A, Ahmad W, Salim A, Dini L, Khan I. Wnt signaling pathway inhibitor promotes mesenchymal stem cells differentiation into cardiac progenitor cells in vitro and improves cardiomyopathy in vivo. World J Stem Cells 2023; 15(8): 821-841 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i8/821.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i8.821 |
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