Publication Name	World Journal of Cardiology
Manuscript ID	8478
Country	United States

Received	2013-12-28 16:29
Peer-Review Started	2013-12-28 21:31
To Make the First Decision	2014-01-23 17:21
Return for Revision	2014-02-24 10:22
Revised	2014-03-06 06:48
Second Decision	2014-04-29 08:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-04-29 08:36
Articles in Press	2014-05-23 09:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-25 09:03
Publish the Manuscript Online	2014-06-26 14:40

ISSN	1949-8462 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Topic Highlights
Article Title	G-protein-coupled estrogen receptor as a new therapeutic target for treating coronary artery disease
Manuscript Source	Invited Manuscript
All Author List	Guichun Han and Richard E White
Funding Agency and Grant Number	Funding Agency Grant Number American Heart Association, Texas Affiliate 7370061 Center for Chronic Disorders of Aging, PCOM
Corresponding Author	Guichun Han, MD, PhD, Women’s Health Division, Michael E DeBakey Institute, Department of Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, MS 4466, College Station, TX 77843, United States. ghan@cvm.tamu.edu
Key Words	G-protein-coupled estrogen receptor; Coronary arteries; G-1; Atherosclerosis; Estrogen
Core Tip	A continuing controversy in cardiology is the impact of estrogen on coronary arteries. This review provides the latest information on the discovery of a novel estrogen receptor in these vessels: the G-protein-coupled estrogen receptor (GPER). Recent findings demonstrate that GPER activation induces coronary artery relaxation and attenuates the proliferation and migration of coronary smooth muscle cells. Thus, GPER appears to be a promising, novel pharmacological target that could increase coronary blood flow in diseased arteries and prevent or reverse the progression of coronary atherosclerotic disease, and do so with potentially fewer dangerous side effects associated with traditional estrogen therapy.
Publish Date	2014-06-26 14:40
Citation	Han G, White RE. G-protein-coupled estrogen receptor as a new therapeutic target for treating coronary artery disease. World J Cardiol 2014; 6(6): 367-375
URL	http://www.wjgnet.com/1949-8462/full/v6/i6/367.htm
DOI	http://dx.doi.org/10.4330/wjc.v6.i6.367

Full Article (PDF)	WJC-6-367.pdf
Full Article (Word)	WJC-6-367.doc
Manuscript File	8478-Review.docx
Answering Reviewers	8478-Answering reviewers.pdf
Copyright License Agreement	8478-Copyright assignment.pdf
Peer-review Report	8478-Peer review(s).pdf
Scientific Editor Work List	8478-Scientific editor work list.doc