| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Dysregulated microRNAs as a biomarker for diagnosis and prognosis of hepatitis B virus-associated hepatocellular carcinoma
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Ming-He Zhang, Yu-Feng Yuan, Li-Juan Liu, Yu-Xin Wei, Wan-Yue Yin, Lan-Zhuo-Yin Zheng, Ying-Ying Tang, Zhao Lv and Fan Zhu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University |
ZNLH201902 |
|
| Corresponding Author |
Fan Zhu, PhD, Professor, State Key Laboratory of Virology, Department of Medical Microbiology, School of Basic Medical Sciences, Wuhan University, No. 185 Donghu Road, Wuhan 430071, Hubei Province, China. fanzhu@whu.edu.cn |
| Key Words |
Hepatitis B virus; Hepatocellular carcinoma; MicroRNA; Diagnosis; Prognosis; Biomarker |
| Core Tip |
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Hepatitis B virus (HBV) infection is one of the predominant risk factors for developing HCC. Early diagnosis and prognosis prediction are pivotal for patients with HBV-associated HCC (HBV-HCC) in their clinical management. MicroRNAs (miRNAs), a subset of non-coding RNAs, play an essential role in human diseases including HBV-HCC. Here, we summarize the role of miRNAs in the diagnosis and prognosis prediction of patients with HBV-HCC. Furthermore, we discuss the underlying mechanism by which HBV dysregulates miRNAs, and the potential role of dysregulated miRNAs in promoting hepatocarcinogenesis, laying the foundation for applying potential therapeutic targets. |
| Publish Date |
2023-08-18 10:08 |
| Citation |
Zhang MH, Yuan YF, Liu LJ, Wei YX, Yin WY, Zheng LZY, Tang YY, Lv Z, Zhu F. Dysregulated microRNAs as a biomarker for diagnosis and prognosis of hepatitis B virus-associated hepatocellular carcinoma. World J Gastroenterol 2023; 29(31): 4706-4735 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i31/4706.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i31.4706 |
