Publication Name	World Journal of Clinical Oncology
Manuscript ID	8508
Country	Mexico

Received	2013-12-29 16:19
Peer-Review Started	2013-12-29 20:00
To Make the First Decision	2014-03-26 15:18
Return for Revision	2014-03-28 13:24
Revised	2014-04-05 04:28
Second Decision	2014-05-19 09:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-19 09:15
Articles in Press	2014-05-23 09:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-24 14:18
Publish the Manuscript Online	2014-08-01 16:16

ISSN	2218-4333 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Topic Highlights
Article Title	Role of IL-10 and TGF-β1 in local immunosuppression in HPV-associated cervical neoplasia
Manuscript Source	Invited Manuscript
All Author List	Kirvis Torres-Poveda, Margarita Bahena-Román, Claudia Madrid-González, Ana I Burguete-García, Víctor Hugo Bermúdez-Morales, Oscar Peralta-Zaragoza and Vicente Madrid-Marina
Funding Agency and Grant Number	Funding Agency Grant Number Instituto Nacional de Salud Pública, Mexico CONACYT-FOSISS, Mexico SALUD-2008-C01-494 87701
Corresponding Author	Vicente Madrid-Marina, MD, PhD, Chronic Infection and Cancer Division, Research Center on Infectious Diseases, Instituto Nacional de Salud Pública, Avenida Universidad 655, Col. Santa María Ahuacatitlán, 62100 Cuernavaca, Morelos. Mexico. vmarina@insp.mx
Key Words	Cervical cancer; Immunosuppression; Interleukin-10; Transforming growth factor-β1; Human Papillomavirus
Core Tip	Human Papillomavirus (HPV) persistence is a key event for cervical cancer development. HPV proteins E2, E6 and E7 induce the transcription of immunosuppressive cytokines as a means of evading HPV the host immune system. We postulate that interleukin-10 and transforming growth factor-β1 induce HPV immune system evasion through an immunosuppressive state in the local microenvironment of the cervix in HPV-infected women. These findings allow us to gain insight in our understanding of how HPV persist in the cervix and favor cervical lesions and cancer development, with potentially strong impact on vaccine development and the design of new targeted immunotherapies for women with cervical neoplasia.
Publish Date	2014-08-01 16:16
Citation	Torres-Poveda K, Bahena-Román M, Madrid-González C, Burguete-García AI, Bermúdez-Morales VH, Peralta-Zaragoza O, Madrid-Marina V. Role of IL-10 and TGF-β1 in local immunosuppression in HPV-associated cervical neoplasia. World J Clin Oncol 2014; 5(4): 753-763
URL	http://www.wjgnet.com/2218-4333/full/v5/i4/753.htm
DOI	http://dx.doi.org/10.5306/wjco.v5.i4.753

Full Article (PDF)	WJCO-5-753.pdf
Full Article (Word)	WJCO-5-753.doc
Manuscript File	8508-Review.doc
Answering Reviewers	8508-Answering reviewers.pdf
Biostatistics Review Certificate	Biostatistician_Review_Report_20131228130936.pdf
Copyright License Agreement	8508-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20131228130846.pdf
Peer-review Report	8508-Peer review(s).pdf
Scientific Editor Work List	8508-Scientific editor work list.pdf