| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Exploring the pharmacological mechanism of Wuzhuyu decoction on hepatocellular carcinoma using network pharmacology
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jia-Ying Ouyang, Wei-Jie Lin, Jia-Mei Dong, Yang Yang, Hai-Kui Yang, Zhi-Ling Zhou and Rui-Qi Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Xiangshan Talented Scientific Research Project of Zhuhai People’s Hospital |
2021XSYC-02 |
| Research Start Project of Zhuhai People’s Hospital |
2020ycqd001 |
|
| Corresponding Author |
Rui-Qi Wang, PhD, Lecturer, Department of Pharmacy, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated with Jinan University), No. 79 Corning Road, Zhuhai 519000, Guangdong Province, China. wangrq2020@ext.jnu.edu.cn |
| Key Words |
Wuzhuyu decoction; Hepatocellular carcinoma; Network pharmacology; Pharmacological mechanism; Bioinformatics |
| Core Tip |
After screening, 6 main active components (Quercetin, Kaempferol, Ginsenoside Rh2, Rutaecarpine, Beta-carotene and Beta-sitosterol) and 10 core genes (tumor necrosis factor, interleukin-6, AKT1, TP53, caspase-3, mitogen-activated protein kinase 1, epidermal growth factor receptor, MYC, MAPK8, JUN) were obtained from Wuzhuyu decoction, and 179 pathways were obtained from Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis, which indicates that multi-component, multi-target and multi-pathway are the mechanism characteristics of Wuzhuyu decoction treating hepatocellular carcinoma (HCC). The active components of Wuzhuyu decoction may participate in these pathways by acting on the top 10 hub genes, which achieves the therapeutic effect of HCC. |
| Publish Date |
2023-09-20 16:48 |
| Citation |
Ouyang JY, Lin WJ, Dong JM, Yang Y, Yang HK, Zhou ZL, Wang RQ. Exploring the pharmacological mechanism of Wuzhuyu decoction on hepatocellular carcinoma using network pharmacology. World J Clin Cases 2023; 11(27): 6327-6343 |
| URL |
https://www.wjgnet.com/2307-8960/full/v11/i27/6327.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v11.i27.6327 |
