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Articles Published Processes
9/13/2023 9:17:50 AM | Browse: 181 | Download: 435
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Received |
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2023-04-11 13:22 |
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Peer-Review Started |
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2023-04-11 13:25 |
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To Make the First Decision |
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Return for Revision |
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2023-07-11 09:33 |
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Revised |
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2023-07-14 19:20 |
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Second Decision |
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2023-07-28 02:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-07-28 07:40 |
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Articles in Press |
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2023-07-28 07:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-09-04 06:34 |
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Publish the Manuscript Online |
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2023-09-13 09:17 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Osteopontin promotes gastric cancer progression via phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yue-Chao Qin, Xin Yan, Xiao-Lin Yuan, Wei-Wei Yu and Fan-Jie Qu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Liaoning Provincial Natural Science Foundation |
No. 201602209 |
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| Corresponding Author |
Fan-Jie Qu, MD, Professor, Department of Oncology, Affiliated Dalian Third People’s Hospital of Dalian Medical University, No. 40 Qianshan Road, Dalian 116033, Liaoning Province, China. wyb960419@163.com |
| Key Words |
Osteopontin; Proliferation; Invasion; Migration; Gastric cancer; Phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway |
| Core Tip |
We investigated the effects of osteopontin (OPN) on the proliferation, invasion and migration of gastric cancer (GC) cells and its possible mechanism. The results of this study revealed that OPN mRNA and protein expression levels were highly expressed in SGC-7901 cells. OPN knockdown by specific short hairpin RNA noticeably reduced the capabilities of proliferation, invasion and migration of SGC-7901 cells. Moreover, our results showed that OPN though phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway signal pathway to up-regulate matrix metalloproteinase 2 and vascular endothelial growth factor expression, which contribute SGC-7901 cells to proliferation, invasion and migration. These results demonstrate that OPN may serve as a novel prognostic biomarkers as well as a potential therapeutic targets for GC. |
| Publish Date |
2023-09-13 09:17 |
| Citation |
Qin YC, Yan X, Yuan XL, Yu WW, Qu FJ. Osteopontin promotes gastric cancer progression via phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway. World J Gastrointest Oncol 2023; 15(9): 1544-1555 |
| URL |
https://www.wjgnet.com/1948-5204/full/v15/i9/1544.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i9.1544 |
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