| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
High spindle and kinetochore-associated complex subunit-3 expression predicts poor prognosis and correlates with adverse immune infiltration in hepatocellular carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lin-Lin Zheng, Ya-Ru Wang, Zhen-Rong Liu, Zhi-Hao Wang, Chang-Cheng Tao, Yong-Gang Xiao, Kai Zhang, An-Ke Wu, Hai-Yang Li, Jian-Xiong Wu, Ting Xiao and Wei-Qi Rong |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Beijing Hope Run Special Fund of Cancer Foundation of China |
LC2020L05 |
|
| Corresponding Author |
Wei-Qi Rong, MD, Professor, Surgeon, Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan South Lane, Beijing 100021, China. dr_rongweiqi@163.com |
| Key Words |
Spindle and kinetochore-associated protein 3; Hepatocellular carcinoma; Prognosis; Immune infiltration cells |
| Core Tip |
In this research, we used biological methods and bioinformatics analyses to explore the mechanisms underlying hepatocellular carcinoma (HCC) progression. We revealed that upregulated spindle and kinetochore-associated complex subunit 3 (SKA3) was substantially correlated with a poor prognosis in patients with HCC. SKA3 expression may facilitate proliferation and migratory processes by regulating the cell cycle and DNA repair. Patients in the high SKA3 expression group had significantly decreased ratios of CD8+ T cells, natural killer cells, and dendritic cells. Our study suggested that high SKA3 expression led to poor prognosis in patients with HCC by enhancing HCC proliferation and repressing immune cell infiltration surrounding HCC. Therefore, SKA3 could serve as a potential biomarker and therapeutic target for HCC. |
| Publish Date |
2023-08-25 12:08 |
| Citation |
Zheng LL, Wang YR, Liu ZR, Wang ZH, Tao CC, Xiao YG, Zhang K, Wu AK, Li HY, Wu JX, Xiao T, Rong WQ. High spindle and kinetochore-associated complex subunit-3 expression predicts poor prognosis and correlates with adverse immune infiltration in hepatocellular carcinoma. World J Gastrointest Surg 2023; 15(8): 1600-1614 |
| URL |
https://www.wjgnet.com/1948-9366/full/v15/i8/1600.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v15.i8.1600 |
