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Articles Published Processes
7/20/2023 9:52:25 AM | Browse: 114 | Download: 217
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Received |
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2023-04-13 16:12 |
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Peer-Review Started |
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2023-04-13 16:15 |
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To Make the First Decision |
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Return for Revision |
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2023-06-01 08:01 |
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Revised |
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2023-06-10 07:30 |
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Second Decision |
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2023-06-29 02:54 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-06-30 03:50 |
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Articles in Press |
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2023-06-30 03:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-07-17 08:23 |
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Publish the Manuscript Online |
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2023-07-20 09:52 |
| ISSN |
2220-3184 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Opinion Review |
| Article Title |
Role of IL-2/IL-2 receptor in pathogenesis of autoimmune disorders: Genetic and therapeutic aspects
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sana Rafaqat and Saira Rafaqat |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Sana Rafaqat, PhD, Research Fellow, Department of Biotechnology (Specialized in Human Genetics), Lahore College for Women University, Lahore 54000, Pakistan. sana.rafaqat44@gmail.com |
| Key Words |
IL-2; IL-2R; Pathogenesis; Autoimmune diseases; Systemic lupus erythematosus; Rheumatoid arthritis; Systemic sclerosis; Sjogren syndrome; Multiple sclerosis |
| Core Tip |
Immune dysregulation of Interleukin-2 (IL-2) may cause tissue injury and damage leads to pathogenesis of various autoimmune diseases The aim of this review paper was to examine the role of IL-2/IL-2R in various autoimmune disorders, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), multiple sclerosis (MS) and Sjogren Syndrome (SS), which are all linked to malfunctioning of IL-2/IL-2R. IL-2 gene polymorphism is involved in increasing the risk of SLE, RA, SSc, and MS but no data has been available about the genetic role of IL-2 in the pathogenesis of Sjogren syndrome. In therapeutic approaches, a low dose of IL-2 therapy is found to be safe, effective, and well-tolerated in the treatment of SLE, RA, SSc, MS, and SS patients. |
| Publish Date |
2023-07-20 09:52 |
| Citation |
Rafaqat S, Rafaqat S. Role of IL-2/IL-2 receptor in pathogenesis of autoimmune disorders: Genetic and therapeutic aspects. World J Med Genet 2023; 11(3): 28-38 |
| URL |
https://www.wjgnet.com/2220-3184/full/v11/i3/28.htm |
| DOI |
https://dx.doi.org/10.5496/wjmg.v11.i3.28 |
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