| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Interferon-γ priming enhances the therapeutic effects of menstrual blood-derived stromal cells in a mouse liver ischemia-reperfusion model
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qi Zhang, Si-Ning Zhou, Jia-Min Fu, Li-Jun Chen, Yang-Xin Fang, Zhen-Yu Xu, Hui-Kang Xu, Yin Yuan, Yu-Qi Huang, Ning Zhang, Yi-Fei Li and Charlie Xiang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key R&D Program of China |
2022YFA1105603, 2022YFC2304405 |
| Hangzhou Science and Technology Project, China |
20200224 |
| National Natural Science Foundation of China |
81900563 |
| Key Research & Development Plan of Zhejiang Province, China |
2019C03015, 2020C04016 |
|
| Corresponding Author |
Charlie Xiang, PhD, Director, Director, Professor, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. cxiang@zju.edu.cn |
| Key Words |
Mesenchymal stem cells; Cell therapy; Reperfusion injury; T-lymphocytes; Autophagy; Liver |
| Core Tip |
In this study, we identified a suitable interferon-γ (IFN-γ) priming strategy for menstrual blood-derived stromal cells (MenSCs) in the liver ischemia-reperfusion (I/R) model and proved that primed MenSCs could significantly increase the number of regulatory cells in the spleen by secreting higher levels of indoleamine 2,3- dioxygenase (IDO) and thereby exhibited better immunoregulatory potential. Besides, through metabolomics and related molecular biology experiments, we found that IDO could reduce ischemia-reperfusion injury via the AMPK-mammalian target of rapamycin-autophagy axis. Our study suggests that IFN-γ-primed MenSCs may be a novel and superior mesenchymal stem cell product for liver transplantation in the future. |
| Publish Date |
2023-09-25 02:36 |
| Citation |
Zhang Q, Zhou SN, Fu JM, Chen LJ, Fang YX, Xu ZY, Xu HK, Yuan Y, Huang YQ, Zhang N, Li YF, Xiang C. Interferon-γ priming enhances the therapeutic effects of menstrual blood-derived stromal cells in a mouse liver ischemia-reperfusion model. World J Stem Cells 2023; 15(9): 876-896 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i9/876.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i9.876 |
