| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Transcriptome sequencing and experiments reveal the effect of formyl peptide receptor 2 on liver homeostasis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hui Liu, Ze-Yu Sun, Hua Jiang, Xu-Dong Li, Yong-Qiang Jiang, Peng Liu, Wen-Hua Huang, Qing-Yu Lv, Xiang-Lilan Zhang and Rong-Kuan Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| State Key Laboratory of Pathogen and Biosecurity |
SKLPBS2119, SKLPBS2212 |
| Medical Science Research Project of Dalian |
2112015 |
|
| Corresponding Author |
Rong-Kuan Li, MD, Chief Doctor, Department of Infectious Diseases, Second Hospital of Dalian Medical University, No. 467 Zhongshan Road, Shahekou District, Dalian 116000, Liaoning Province, China. dalianlrk1@163.com |
| Key Words |
Cell cycle; Cell proliferation; Cdk1; Differentially expressed genes; Formyl peptide receptor 2; RNA-sequencing |
| Core Tip |
Formyl peptide receptor 2 (Fpr2) is an important receptor in host resistance to bacterial infection. After Fpr2 deletion, the pathways involved in the cell cycle are affected, the expression of Cdk1 is downregulated, the proliferation activity of HepG2 cells is reduced, and the distribution of cell cycle is abnormal. After Fpr2 deletion, the permeability of the hepatocyte membrane increases, and the expression of interleukin-10 and Chemokine (C-X-C motif) ligand-1 decreases. These changes reflect the important protective effect of Fpr2 in maintaining liver homeostasis. |
| Publish Date |
2023-06-28 10:03 |
| Citation |
Liu H, Sun ZY, Jiang H, Li XD, Jiang YQ, Liu P, Huang WH, Lv QY, Zhang XL, Li RK. Transcriptome sequencing and experiments reveal the effect of formyl peptide receptor 2 on liver homeostasis. World J Gastroenterol 2023; 29(24): 3793-3806 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i24/3793.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i24.3793 |
