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Articles Published Processes
8/25/2023 7:09:14 AM | Browse: 218 | Download: 631
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Received |
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2023-05-20 15:52 |
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Peer-Review Started |
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2023-05-20 15:55 |
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To Make the First Decision |
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Return for Revision |
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2023-06-22 03:43 |
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Revised |
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2023-07-06 02:54 |
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Second Decision |
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2023-07-31 02:56 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-07-31 20:09 |
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Articles in Press |
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2023-07-31 20:09 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-08-21 10:57 |
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Publish the Manuscript Online |
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2023-08-25 07:09 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Different oncological features of colorectal cancer codon-specific KRAS mutations: Not codon 13 but codon 12 have prognostic value
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hong-Min Ahn, Duck-Woo Kim, Hyeon Jeong Oh, Hyung Kyung Kim, Hye Seung Lee, Tae Gyun Lee, Hye-Rim Shin, In Jun Yang, Jeehye Lee, Jung Wook Suh, Heung-Kwon Oh and Sung-Bum Kang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Duck-Woo Kim, MD, PhD, Professor, Department of Surgery, Seoul National University Bundang Hospital, 166 Gumi-ro, Bundang-gu, Seongnam 13620, South Korea. kdw@snubh.org |
| Key Words |
Genes; Ras; Codon; Colonic neoplasms; Rectal neoplasms |
| Core Tip |
Based on a large-scale cohort of patients with stage I-III colorectal cancer (CRC), Kirsten rat sarcoma viral oncogene homolog (KRAS) codon 13 mutation is less pathogenic and recurrent. Moreover, focusing on the biological effects of codon-specific KRAS mutations and minimizing interference with various medical therapies, previous in vivo studies demonstrating that KRAS codon 13 mutation is less aggressive were translated into clinical outcomes in this study. This may influence many oncologists to consult with patients on their prognosis after surgery. We propose that KRAS codon 13 mutation is less likely to serve as a prognostic factor of CRC, compared with codon 12. |
| Publish Date |
2023-08-25 07:09 |
| Citation |
Ahn HM, Kim DW, Oh HJ, Kim HK, Lee HS, Lee TG, Shin HR: Yang IJ, Lee J, Suh JW, Oh HK, Kang SB. Different oncological features of colorectal cancer codon-specific KRAS mutations: Not codon 13 but codon 12 have prognostic value. World J Gastroenterol 2023; 29(32): 4883-4899 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i32/4883.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i32.4883 |
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