| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Quercetin ameliorates oxidative stress-induced senescence in rat nucleus pulposus-derived mesenchymal stem cells via the miR-34a-5p/SIRT1 axis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Jie Zhao, Xin Liu, Man Hu, Yu Zhang, Peng-Zhi Shi, Jun-Wu Wang, Xu-Hua Lu, Xiao-Fei Cheng, Yu-Ping Tao, Xin-Min Feng, Yong-Xiang Wang and Liang Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
82172462 and 81972136 |
| the Traditional Chinese Medicine Science and Technology Development Plan Project of Jiangsu Province |
YB2020085 |
| Cross Cooperation Project of Northern Jiangsu People’s Hospital |
SBJC21014 |
|
| Corresponding Author |
Liang Zhang, PhD, Professor, Department of Orthopedics, Clinical Medical College, Yangzhou University, No. 98 Nantong West Road, Yangzhou 225001, Jiangsu Province, China. zhangliang6320@sina.com |
| Key Words |
Quercetin; Nucleus pulposus-derived mesenchymal stem cells; Oxidative stress; Senescence; Intervertebral disc degeneration; miR-34a-5p/SIRT1 pathway |
| Core Tip |
In our article, we provide the evidence that quercetin (Que) can prevent oxidative stress induced senescence of nucleus pulposus-derived mesenchymal stem cells via miR-34a/SIRT1 signaling pathway. Moreover, Que could ameliorate the progression of intervertebral disc degeneration (IDD) in rat model. Thus, Que can be considered as a potential agent for the treatment of IDD. |
| Publish Date |
2023-08-25 07:59 |
| Citation |
Zhao WJ, Liu X, Hu M, Zhang Y, Shi PZ, Wang JW, Lu XH, Cheng XF, Tao YP, Feng XM, Wang YX, Zhang L. Quercetin ameliorates oxidative stress-induced senescence in rat nucleus pulposus-derived mesenchymal stem cells via the miR-34a-5p/SIRT1 axis. World J Stem Cells 2023; 15(8): 842-865 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i8/842.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i8.842 |
