Publication Name	World Journal of Clinical Oncology
Manuscript ID	8531
Country	China

Received	2013-12-30 09:23
Peer-Review Started	2013-12-30 14:15
To Make the First Decision	2014-03-12 17:02
Return for Revision	2014-03-20 18:31
Revised	2014-04-17 07:05
Second Decision	2014-06-11 14:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-06-11 14:26
Articles in Press	2014-06-11 15:00
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-06-16 06:46
Typeset the Manuscript	2014-07-24 14:16
Publish the Manuscript Online	2014-08-01 16:16

ISSN	2218-4333 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Acetylcholine receptor pathway in lung cancer: New twists to an old story
Manuscript Source	Invited Manuscript
All Author List	Xiao-Min Niu and Shun Lu
Funding Agency and Grant Number	Funding Agency Grant Number Youth Foundation of Shanghai Municipal Public Health Bureau 20124Y114 Shanghai Chest Hospital “1050 Talents Project”, China Project of Shanghai Chest Hospital YZ13-16
Corresponding Author	Shun Lu, MD, PhD, Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, 241 Huaihai West Road, Shanghai 200030, China. shun_lu@hotmail.com
Key Words	Acetylcholine receptor; Pathway; CHRNA; Nicotine; Pulmonary carcinoma
Core Tip	Genome-wide association studies revealed that allelic variation in the ?5-?3-?4 nicotine acetylcholine receptor (nAChR) cluster on chromosome 15q24-15q25.1 was associated with a higher risk for development of lung cancer. nAChRs are membrane ligand-gated cation channels whose activation is triggered by the binding of the endogenous neurotransmitter acetylcholine (ACh) or other biologic compounds including nicotine. nAChRs have been found on lung cancer cells, underscoring the idea that the non-neuronal nAChR signaling pathway has considerable implications for lung cancer. Several studies involving the design of nAChR antagonists with improved selectivity might identify novel strategies for the treatment of lung cancer.
Publish Date	2014-08-01 16:16
Citation	Niu XM, Lu S. Acetylcholine receptor pathway in lung cancer: New twists to an old story. World J Clin Oncol 2014; 5(4): 667-676
URL	http://www.wjgnet.com/2218-4333/full/v5/i4/667.htm
DOI	http://dx.doi.org/10.5306/wjco.v5.i4.667

Full Article (PDF)	WJCO-5-667.pdf
Full Article (Word)	WJCO-5-667.doc
Manuscript File	8531-Review.doc
Answering Reviewers	8531-Answering reviewers.pdf
Copyright License Agreement	8531-Copyright assignment.pdf
Peer-review Report	8531-Peer review(s).pdf
Scientific Misconduct Check	8531-CrossCheck.jpg
Scientific Editor Work List	8531-Scientific editor work list.pdf