Publication Name	World Journal of Cardiology
Manuscript ID	8535
Country	Brazil

Received	2013-12-30 09:38
Peer-Review Started	2013-12-30 14:31
To Make the First Decision	2014-01-23 17:21
Return for Revision	2014-02-24 10:17
Revised	2014-03-14 03:31
Second Decision	2014-04-19 14:25
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-19 14:36
Articles in Press	2014-05-23 09:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-25 09:02
Publish the Manuscript Online	2014-06-26 14:40

ISSN	1949-8462 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Topic Highlights
Article Title	Impact of conditioning hyperglycemic on myocardial infarction rats: Cardiac cell survival factors
Manuscript Source	Invited Manuscript
All Author List	Christiane Malfitano, Alcione Lescano de Souza Junior and Maria Cláudia Irigoyen
Funding Agency and Grant Number
Corresponding Author	Christiane Malfitano, PhD, Universidade Nove de Julho-Medicine Program, Rua Vergueiro 235/249-2° subsolo-Mestrado, 01504001 Sao Paulo, Brazil. chrismalfi@hotmail.com
Key Words	Conditioned hyperglycemia; Diabetes mellitus; Myocardial infarction; Cardioprotection; Survival factors
Core Tip	Hyperglycemia or diabetes triggers a conditioned state that may protect the heart against ischemic injury and associated detrimental effects. These beneficial effects are present in short term diabetes and/or moderate hyperglycemia. The increase in glucose availability, the preferred energy substrate of the heart in stress condition, is likely to be one of the main cardioprotector mechanisms of hyperglycemia. However, other cardioprotective mechanisms seem to be involved, such as the release of cellular survival factors, ions preventing overload and angiogenesis. A fuller understanding of the mechanisms underlying conditioned hyperglycemia is then critical for the development of effective therapeutic strategies against ischemic heart disease.
Publish Date	2014-06-26 14:40
Citation	Malfitano C, de Souza Junior AL, Irigoyen MC. Impact of conditioning hyperglycemic on myocardial infarction rats: Cardiac cell survival factors. World J Cardiol 2014; 6(6): 449-454
URL	http://www.wjgnet.com/1949-8462/full/v6/i6/449. htm
DOI	http://dx.doi.org/10.4330/wjc.v6.i6.449

Full Article (PDF)	WJC-6-449.pdf
Full Article (Word)	WJC-6-449.doc
Manuscript File	8535-Review.doc
Answering Reviewers	8535-Answering Reviewers.pdf
Copyright License Agreement	8535-Copyright assignment.pdf
Peer-review Report	8535-Peer review(s).pdf
Scientific Editor Work List	8535-Scientific editor work list.doc