Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	85410
Country	China

Received	2023-04-28 09:07
Peer-Review Started	2023-04-28 09:09
First Decision by Editorial Office Director	2023-07-23 22:39
Return for Revision	2023-07-24 01:37
Revised	2023-08-04 09:35
Publication Fee Transferred
Second Decision by Editor	2023-08-16 02:59
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2023-08-17 02:11
Articles in Press	2023-08-17 02:11
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-09-26 15:58
Publish the Manuscript Online	2023-10-27 10:13

ISSN	1948-9366 (online)
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Category	Geriatrics & Gerontology
Manuscript Type	Retrospective Study
Article Title	Gene polymorphisms associated with sudden decreases in heart rate during extensive peritoneal lavage with distilled water after gastrectomy
Manuscript Source	Unsolicited Manuscript
All Author List	Shuang Yao, Yan Yuan, Jun Zhang, Yang Yu and Guang-Hua Luo
ORCID	Author(s) ORCID Number Shuang Yao http://orcid.org/0000-0003-3686-5404 Yan Yuan http://orcid.org/0000-0002-1310-9107 Jun Zhang http://orcid.org/0000-0002-1826-6099 Yang Yu http://orcid.org/0000-0002-9258-786X Guang-Hua Luo http://orcid.org/0000-0001-8339-2828
Funding Agency and Grant Number	Funding Agency Grant Number Changzhou Sci and Tech Program No. CJ20210113 Changzhou Health Young Talents Plan No. CZQM2021006
Corresponding Author	Guang-Hua Luo, PhD, Chief Technician, Clinical Medical Research Center, the Third Affiliated Hospital of Soochow University, No. 185 Juqian Street, Changzhou 213000, Jiangsu Province, China. shineroar@163.com
Key Words	Homo sapiens RecQ like helicase 5; Telomerase-associated protein 1; Polymorphism; Peritoneal lavage; Heart rate variability; Two-dimensional polymerase chain reaction
Core Tip	Our previous study found that peritoneal lavage with distilled water may cause a sudden decrease in heart rate (HR) in some patients during clinical gastrectomy, which was related to telomerase-associated protein 1 and homo sapiens RecQ like helicase 5 gene polymorphisms. Here, instead of Sanger sequencing, we developed a single-tube method using two-dimensional polymerase chain reaction to genotyping single nucleotide polymorphisms (SNPs) quickly and economically. We also investigated whether genotypes, genetic patterns and the interaction effects of SNP-SNP and SNP-environment were associated with a risk of high HR variability. This study helps clinicians to better assess the perioperative risk of patients undergoing gastrectomy.
Publish Date	2023-10-27 10:13
Citation	Yao S, Yuan Y, Zhang J, Yu Y, Luo GH. Gene polymorphisms associated with sudden decreases in heart rate during extensive peritoneal lavage with distilled water after gastrectomy. World J Gastrointest Surg 2023; 15(10): 2154-2170
URL	https://www.wjgnet.com/1948-9366/full/v15/i10/2154.htm
DOI	https://dx.doi.org/10.4240/wjgs.v15.i10.2154

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