Publication Name	World Journal of Clinical Oncology
Manuscript ID	8543
Country	United States

Received	2013-12-30 10:38
Peer-Review Started	2013-12-30 11:13
To Make the First Decision	2014-02-27 10:49
Return for Revision	2014-03-04 20:58
Revised	2014-03-22 00:04
Second Decision	2014-06-20 11:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-20 12:06
Articles in Press	2014-06-20 13:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-24 14:16
Publish the Manuscript Online	2014-08-01 16:16

ISSN	2218-4333 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Management of tyrosine kinase inhibitor resistance in lung cancer with EGFR mutation
Manuscript Source	Invited Manuscript
All Author List	Kevin Becker and Yiqing Xu
Funding Agency and Grant Number
Corresponding Author	Kevin Becker, MD, Division of Hematology and Oncology, Maimonides Cancer Center, 6300 Eighth Ave, Brooklyn, NY 11201, United States. kbecker@maimonidesmed.org
Key Words	Epidermal growth factor receptor mutation; Tyrosine kinase inhibitor; Lung cancer; Adenocarcinoma; Resistance; Targeted therapy
Core Tip	The causes of epidermal growth factor receptor tyrosine kinase inhibitor (TKI) treatment failure including pharmacokinetic failure, intrinsic resistance and acquired resistance are discussed. We review the molecular mechanisms of resistance and the options for clinical management of disease progression. Promising investigational strategies for overcoming TKI resistance are highlighted.
Publish Date	2014-08-01 16:16
Citation	Becker K, Xu Y. Management of tyrosine kinase inhibitor resistance in lung cancer with EGFR mutation. World J Clin Oncol 2014; 5(4): 560-567
URL	http://www.wjgnet.com/2218-4333/full/v5/i4/560.htm
DOI	http://dx.doi.org/10.5306/wjco.v5.i4.560

Full Article (PDF)	WJCO-5-560.pdf
Full Article (Word)	WJCO-5-560.doc
Manuscript File	8543-Review.docx
Answering Reviewers	8543-Answering reviewers.pdf
Copyright License Agreement	8543-Copyright assignment.pdf
Peer-review Report	8543-Peer review(s).pdf
Scientific Misconduct Check	8543-CrossCheck.jpg
Scientific Editor Work List	8543-Scientific editor work list.pdf