| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Observational Study |
| Article Title |
Hyperthermia combined with chemotherapy vs chemotherapy in patients with advanced pancreatic cancer: A multicenter retrospective observational comparative study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Giammaria Fiorentini, Donatella Sarti, Andrea Mambrini, Ivano Hammarberg Ferri, Massimo Bonucci, Paola Giordano Sciacca, Marco Ballerini, Salvatore Bonanno, Carlo Milandri, Roberto Nani, Stefano Guadagni, Patrizia Dentico and Caterina Fiorentini |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Giammaria Fiorentini, MD, Adjunct Professor, Chief Doctor, Director, Director, Integrative Oncology, Integrative Oncology Outpatient Clinic, Via dell'Indipendenza, 20, Bologna 40121, Italy. g.fiorentini@alice.it |
| Key Words |
Modulated electro hyperthermia; Locally advanced pancreatic tumor; Overall survival; Tumor response; Gemcitabine; Apoptosis; Immunogenic cell death |
| Core Tip |
Pancreatic cancer has very poor prognosis with a 5-year overall survival of 5% and a median overall survival (OS) time of 8-12 mo. The concomitant use of modulated electro-hyperthermia (mEHT) in addition to chemotherapy has been introduced. mEHT has specific antitumor effects, increasing survival and tumor response. This was a retrospective data collection on 217 patients affected by locally advanced pancreatic cancer performed in 9 Italian centres, aiming to assess survival, tumour response and toxicity. The mEHT group had a greater OS (20 mo vs 9 mo, P < 0.001), higher number of partial responses (45% vs 24%, P = 0.0018) and a lower number of progressions (4% vs 31%, P < 0.001) than no-mEHT group. Adverse events were observed in 2.6% of mEHT sessions. mEHT have beneficial effects on survival and tumor response of stage III-IV pancreatic tumor patients, without adding toxicity. |
| Publish Date |
2023-06-21 02:14 |
| Citation |
Fiorentini G, Sarti D, Mambrini A, Ferri IH, Bonucci M, Sciacca PG, Ballerini M, Bonanno S, Milandri C, Nani R, Guadagni S, Dentico P, Fiorentini C. Efficacy and safety of hyperthermia alone or in combination with chemotherapy vs chemotherapy in patients with advanced pancreatic cancer: A multicenter retrospective observational comparative study on 217 patients. World J Clin Oncol 2023; 14(6): 215-226 |
| URL |
https://www.wjgnet.com/2218-4333/full/v14/i6/215.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v14.i6.215 |
