BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
9/25/2023 2:36:45 AM | Browse: 317 | Download: 1226
 |
Received |
|
2023-07-27 03:04 |
|
Peer-Review Started |
|
2023-07-27 03:04 |
|
First Decision by Editorial Office Director |
|
2023-08-03 22:36 |
|
Return for Revision |
|
2023-08-03 22:36 |
|
Revised |
|
2023-08-16 09:58 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2023-09-12 02:46 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2023-09-12 20:29 |
|
Articles in Press |
|
2023-09-12 20:29 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2023-09-18 10:47 |
|
Publish the Manuscript Online |
|
2023-09-25 02:36 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Mechanism of adipose-derived mesenchymal stem cell exosomes in the treatment of heart failure
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lei Wang, Jin-Jin Zhang, Sha-Sha Wang and Liang Li |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Liang Li, MM, Doctor, Doctor, Department of Geriatric Medicine, Fourth Medical Center of PLA General Hospital, No. 51 Fucheng road, Haidian District, Beijing 100048, China. liliangcc@163.com |
| Key Words |
Adipose-derived mesenchymal stem cell exosomes; Heart failure; Cardiomyocyte apoptosis |
| Core Tip |
Our study highlights the potential of mesenchymal stem cell exosomes (Exos) from adipose tissue as a promising therapy for heart failure (HF). Administration of adipose-derived mesenchymal stem cell Exos improved cardiac function, evidenced by increased ATP content and enhanced parameters like ejection fraction, fractional shortening, and stroke volume. Furthermore, adipose-derived stem cells (ADSCs)-Exo reduced serum levels of b-type natriuretic peptide and atrial natriuretic peptide, associated with HF progression, and exhibited anti-apoptotic effects by regulating pro- and anti-apoptotic proteins in cardiac tissue. These findings suggest that ADSCs-Exo could prevent cardiomyocyte death and inhibit HF progression. |
| Publish Date |
2023-09-25 02:36 |
| Citation |
Wang L, Zhang JJ, Wang SS, Li L. Mechanism of adipose-derived mesenchymal stem cell exosomes in the treatment of heart failure. World J Stem Cells 2023; 15(9): 897-907
|
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i9/897.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i9.897 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
