Publication Name	World Journal of Clinical Oncology
Manuscript ID	8548
Country	Germany

Received	2013-12-30 10:54
Peer-Review Started	2013-12-30 14:58
To Make the First Decision	2014-01-08 14:12
Return for Revision	2014-01-21 16:20
Revised	2014-02-10 23:24
Second Decision	2014-03-17 14:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-17 14:49
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-07 14:41
Publish the Manuscript Online	2014-05-12 18:06

ISSN	2218-4333 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Squamous cell carcinoma of the oral cavity and circulating tumour cells
Manuscript Source	Invited Manuscript
All Author List	Johannes Wikner, Alexander Gröbe, Klaus Pantel and Sabine Riethdorf
Funding Agency and Grant Number	Funding Agency Grant Number Hamburger Stiftung zur Förderung der Krebsbekämpfung 188(to Gröbe A and Riethdorf S) ERC Advanced Investigator Grant “DISSECT” 269081(to Pantel K)
Corresponding Author	Sabine Riethdorf, PhD, Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. s.riethdorf@uke.de
Key Words	Circulating tumour cells; Disseminated tumour cells; Oral squamous cell carcinoma; Head and neck squamous cell carcinoma; Bone marrow; Peripheral blood; Micrometastasis; Minimal residual disease; Epithelial-mesenchymal transition
Core Tip	Oral squamous cell carcinoma (OSCC), among head and neck cancer, is related to poor survival rates despite considerable advances in diagnosis and treatment. Therefore, detecting tumour cell dissemination early and understanding the underlying mechanisms are crucial for predicting prognosis, relapse and survival. According to previous findings, circulating tumour cells (CTCs) and disseminated tumour cells (DTCs) might serve as prognostic markers to supplement routine staging and support determining individual therapeutic interventions. This review focuses on summarising the current knowledge about the detection of CTCs/DTCs with special emphasis on patients suffering from OSCC. The translational relevance of CTCs/DTCs and challenges for clinical application are highlighted.
Publish Date	2014-05-12 18:06
Citation	Wikner J, Gröbe A, Pantel K, Riethdorf S. Squamous cell carcinoma of the oral cavity and circulating tumour cells. World J Clin Oncol 2014; 5(2): 114-124
URL	http://www.wjgnet.com/2218-4333/full/v5/i2/114.htm
DOI	http://dx.doi.org/10.5306/wjco.v5.i2.114

Full Article (PDF)	WJCO-5-114.pdf
Full Article (Word)	WJCO-5-114.doc
Manuscript File	8548-Review.doc
Answering Reviewers	8548-Answering reviewers.pdf
Copyright License Agreement	8548-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	8548-Language certificate.pdf
Peer-review Report	8548-Peer reviewer(s).pdf
Scientific Editor Work List	8548-Scientific editor work list.doc