| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
MiR-204-3p overexpression inhibits gastric carcinoma cells proliferation via inhibiting the MAPK pathway and RIP1/MLK1 necroptosis pathway to promote apoptosis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xia Li, Joanna J Tibenda, Yi Nan, Shi-Cong Huang, Na Ning, Guo-Qing Chen, Yu-Hua Du, Ya-Ting Yang, Fan-Di Meng and Ling Yuan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ningxia Natural Science Foundation |
2022AAC03144 |
|
| Corresponding Author |
Ling Yuan, PhD, Professor, College of Pharmacy, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China. 20080017@nxmu.edu.cn |
| Key Words |
miR-204-3p; Gastric carcinoma; MAPK signaling pathway; Apoptosis; Necroptosis |
| Core Tip |
Gastric carcinoma (GC) is a global health problem that seriously endangers human life, therefore, it is important to find effective treatment targets. In this regard, microRNAs (miRNAs) have emerged as a promising therapeutic strategy. Studies have shown that miRNAs regulated signaling pathways, acting as tumor suppressors or tumor promoters. In this paper, we first verified the inhibitory effect of miR-204-3p overexpression on GC cells through in vitro and in vivo experiments. Simultaneously, miR-204-3p overexpression induced GC cells apoptosis by inhibiting the MAPK pathway, as well as inhibiting the necroptosis. Thus, miR-204-3p may represent a new potential therapeutic target for GC. |
| Publish Date |
2023-08-02 09:29 |
| Citation |
Li X, Tibenda JJ, Nan Y, Huang SC, Ning N, Chen GQ, Du YH, Yang YT, Meng FD, Yuan L. MiR-204-3p overexpression inhibits gastric carcinoma cells proliferation via inhibiting the MAPK pathway and RIP1/MLK1 necroptosis pathway to promote apoptosis. World J Gastroenterol 2023; 29(29): 4542-4556 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i29/4542.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i29.4542 |
