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Articles Published Processes
8/17/2023 7:08:15 AM | Browse: 77 | Download: 188
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Received |
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2023-06-06 10:32 |
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Peer-Review Started |
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2023-06-06 10:32 |
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To Make the First Decision |
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Return for Revision |
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2023-06-21 09:18 |
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Revised |
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2023-07-06 09:25 |
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Second Decision |
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2023-07-26 02:55 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-07-27 00:23 |
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Articles in Press |
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2023-07-27 00:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-08-14 06:49 |
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Publish the Manuscript Online |
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2023-08-17 07:08 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Clinical Neurology |
| Manuscript Type |
Basic Study |
| Article Title |
Dexmedetomidine mediates the mechanism of action of ferroptosis in mice with Alzheimer’s disease by regulating the mTOR-TFR1 pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li Qiao, Gang Li and Hong-Xun Yuan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Peking University International Hospital Foundation for Scientific Research |
YN2022QN11 |
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| Corresponding Author |
Gang Li, MBBS, Chief Physician, Intensive Care Unit, Peking University International Hospital, No. 1 Life Park Road, Zhongguancun Life Science Park, Changping District, Beijing 102206, China. ligang1@pkuih.edu.cn |
| Key Words |
Dexmedetomidine; Ferroptosis; Alzheimer’s disease; Mammalian target of rapamycin; Mice |
| Core Tip |
Iron death of nerve cells caused by iron overload is an important factor in various neurodegenerative diseases, including Alzheimer’s disease (AD). The classic mammalian target of rapamycin (mTOR) signaling pathway regulates the metabolism of iron ions by regulating transferrin receptor 1 (TFR1), thereby maintaining the intracellular iron balance. It has been shown that dexmedetomidine (Dex) inhibits the release of inflammatory factors and plays a neuroprotective role, thereby improving cognitive dysfunction in elderly rats. The Dex effectively improved hippocampal neuronal loss, cognitive dysfunction, learning and memory abilities in AD mice by regulating the mTOR-TFR1 signaling pathway to reduce iron death. |
| Publish Date |
2023-08-17 07:08 |
| Citation |
Qiao L, Li G, Yuan HX. Dexmedetomidine mediates the mechanism of action of ferroptosis in mice with Alzheimer’s disease by regulating the mTOR-TFR1 pathway. World J Psychiatry 2023; 13(8): 511-523 |
| URL |
https://www.wjgnet.com/2220-3206/full/v13/i8/511.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v13.i8.511 |
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