| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Evidence-Based Medicine |
| Article Title |
Management of nonalcoholic fatty liver disease: An evidence-based clinical practice review
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Juan P Arab, Roberto Candia, Rodrigo Zapata, Cristián Muñoz, Juan P Arancibia, Jaime Poniachik, Alejandro Soza, Francisco Fuster, Javier Brahm, Edgar Sanhueza, Jorge Contreras, M Carolina Cuellar, Marco Arrese and Arnoldo Riquelme |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chilean Society of Gastroenterology (in part) |
|
| Fondo Nacional De Ciencia y Tecnología de Chile |
1110455 (to Arrese M) |
| Fondo Nacional De Ciencia y Tecnología de Chile |
1120652 (to Riquelme A) |
| Comisión Nacional de Investigación, Ciencia y Tecnología, CONICYT |
|
|
| Corresponding Author |
Arnoldo Riquelme, MD, MMedEd, Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Marcoleta 367, 8330024 Santiago, Chile. a.riquelme.perez@gmail.com |
| Key Words |
Nonalcoholic fatty liver disease; Steatosis; Consensus; Evidence-based medicine; Treatment |
| Core Tip |
Current nonalcoholic fatty liver disease (NAFLD) management is rapidly evolving, and new pathophysiology-based therapies are expected to be introduced in the near future. All NAFLD patients should be evaluated using a three-focused approach that considers risks of liver disease, diabetes and cardiovascular events. The final recommendations of this consensus support the indication of lifestyle changes, including diet and exercise, for all patients with NAFLD. Proven pharmacological therapies only consider vitamin E and pioglitazone, which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis (the progressive form of NAFLD), although the long-term safety and efficacy of these therapies have not been established. |
| Publish Date |
2014-09-18 19:50 |
| Citation |
Arab JP, Candia R, Zapata R, Muñoz C, Arancibia JP, Poniachik J, Soza A, Fuster F, Brahm J, Sanhueza E, Contreras J, Cuellar MC, Arrese M, Riquelme A. Management of nonalcoholic fatty liver disease: An evidence-based clinical practice review. World J Gastroenterol 2014; 20(34): 12182-12201 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i34/12182.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i34.12182 |
