BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
9/13/2023 12:15:07 PM | Browse: 216 | Download: 482
 |
Received |
|
2023-05-24 01:18 |
|
Peer-Review Started |
|
2023-05-24 01:18 |
 |
To Make the First Decision |
|
|
|
Return for Revision |
|
2023-06-12 02:39 |
|
Revised |
|
2023-07-06 08:58 |
|
Second Decision |
|
2023-07-26 03:29 |
|
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2023-08-02 06:09 |
|
Articles in Press |
|
2023-08-02 06:09 |
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2023-09-07 06:49 |
|
Publish the Manuscript Online |
|
2023-09-13 12:15 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
XB130 inhibits healing of diabetic skin ulcers through the PI3K/Akt signalling pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xin-Lin Zhu, Dong-Ying Hu, Zhao-Xiang Zeng, Wei-Wei Jiang, Tian-Yang Chen, Tian-Cheng Chen, Wan-Qing Liao, Wen-Zhi Lei, Wen-Jie Fang and Wei-Hua Pan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
82272355 |
| Shanghai Science and Technology Committee |
21410750500 |
|
| Corresponding Author |
Wei-Hua Pan, PhD, Chief Doctor, Department of Dermatology, Shanghai Key Laboratory of Medical Mycology, Changzheng Hospital, Naval Medical University, No. 415 Fengyang Road, Shanghai 200003, China. panweihua9@sina.com |
| Key Words |
XB130; Diabetes mellitus; Diabetic skin ulcers; PI3K/Akt signalling pathway |
| Core Tip |
The role of XB130 in the occurrence and development of diabetic skin ulcers healing is unclear. This study showed that the expression of XB130 was up-regulated in tissues of diabetic skin ulcers and human umbilical vein endothelial cells (HUVECs) stimulated by high glucose. Knockdown of XB130 promote the healing of skin wounds in mice, leading to an accelerated wound healing process and shortened wound healing time and alleviated hyperglycemia-induced cell proliferation inhibition and angiogenic impairment in HUVECs. |
| Publish Date |
2023-09-13 12:15 |
| Citation |
Zhu XL, Hu DY, Zeng ZX, Jiang WW, Chen TY, Chen TC, Liao WQ, Lei WZ, Fang WJ, Pan WH. XB130 inhibits healing of diabetic skin ulcers through the PI3K/Akt signalling pathway. World J Diabetes 2023; 14(9): 1369-1384 |
| URL |
https://www.wjgnet.com/1948-9358/full/v14/i9/1369.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i9.1369 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
