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Articles Published Processes
9/25/2023 2:36:45 AM | Browse: 202 | Download: 674
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Received |
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2023-05-12 01:56 |
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Peer-Review Started |
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2023-05-12 01:59 |
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To Make the First Decision |
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Return for Revision |
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2023-06-29 16:53 |
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Revised |
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2023-07-23 15:50 |
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Second Decision |
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2023-08-21 03:36 |
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Accepted by Journal Editor-in-Chief |
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2023-08-23 17:20 |
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Accepted by Executive Editor-in-Chief |
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2023-09-07 15:49 |
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Articles in Press |
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2023-09-07 15:49 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-08-18 08:27 |
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Typeset the Manuscript |
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2023-09-20 00:23 |
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Publish the Manuscript Online |
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2023-09-25 02:36 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Respiratory System |
| Manuscript Type |
Basic Study |
| Article Title |
Multiomics reveal human umbilical cord mesenchymal stem cells improving acute lung injury via the lung-gut axis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lu Lv, En-Hai Cui, Bin Wang, Li-Qin Li, Feng Hua, Hua-Dong Lu, Na Chen and Wen-Yan Chen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key Research and Development Project of Science and Technology Department of Zhejiang Province |
2019C03041 |
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| Corresponding Author |
En-Hai Cui, BM BCh, Doctor, Doctor, Department of Respiratory and Critical Care Medicine, Huzhou Central Hospital, Affiliated Huzhou Hospital, Zhejiang University School of Medicine, No. 1558 Third Ring North Road, Huzhou 313000, Zhejiang Province, China. kjkceh@126.com |
| Key Words |
Acute lung injury; Human umbilical cord mesenchymal cells; Lipopolysaccharide; Microflora; Untargeted metabolomics; Toll-like receptor 4/nuclear factor kappa-B signaling pathway |
| Core Tip |
The results of this study suggest that human umbilical cord mesenchymal cells (HUC-MSCs) inhibit the inflammatory cytokine expression levels in serum and the lung of mice with acute lung injury (ALI), which may be achieved by redefining the gut and lung microbiota. This study not only provides a scientific basis for the pathophysiological mechanisms and clinical application of HUC-MSCs, but it also provides new ideas for the development of therapeutic strategies for ALI. |
| Publish Date |
2023-09-25 02:36 |
| Citation |
Lv L, Cui EH, Wang B, Li LQ, Hua F, Lu HD, Chen N, Chen WY. Correlation between gut and lung microbiota homeostases and human umbilical cord mesenchymal stem cells in acute lung injury. World J Stem Cells 2023; 15(9): 908-930 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i9/908.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i9.908 |
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