| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
F-box only protein 2 exacerbates non-alcoholic fatty liver disease by targeting the hydroxyl CoA dehydrogenase alpha subunit
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi Liu, Ning-Yuan Chen, Zhao Zhang, Sai Zhou and San-Yuan Hu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82070869, 82270914 |
|
| Corresponding Author |
San-Yuan Hu, Doctor, MD, Chief Doctor, Chief Physician, Doctor, Doctor, Full Professor, Professor, Surgeon, Department of General Surgery, Qilu Hospital of Shandong University, No. 107 West Wenhua Road, Jinan 250012, Shandong Province, China. husanyuan1962@hotmail.com |
| Key Words |
F-box only protein 2; Nonalcoholic fatty liver disease; The hydroxyl CoA dehydrogenase alpha subunit; Liver steatosis; Ubiquitination; Lipid accumulation |
| Core Tip |
This study involves an assessment of the role of F-box only protein 2 (FBXO2) in non-alcoholic fatty liver disease (NAFLD). First, based on the whole genome sequencing analysis results of liver tissues from normal controls and patients with NAFLD, the expression of FBXO2 was found to be increased during NAFLD. Hepatocyte-specific FBXO2 overexpression facilitated NAFLD-associated phenotypes in mice. In contrast, the knockdown of FBXO2 expression of HepG2 cells significantly alleviated oleate-induced lipid accumulation. Mechanistically, the hydroxyl CoA dehydrogenase alpha subunit, a protein with known role in oxidative stress reaction, is one of the protein substrates of FBXO2-mediated ubiquitination. |
| Publish Date |
2023-07-26 11:55 |
| Citation |
Liu Z, Chen NY, Zhang Z, Zhou S, Hu SY. F-box only protein 2 exacerbates non-alcoholic fatty liver disease by targeting the hydroxyl CoA dehydrogenase alpha subunit. World J Gastroenterol 2023; 29(28): 4433-4450 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i28/4433.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i28.4433 |
