| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Clinical characteristics and outcome of autoimmune pancreatitis based on serum immunoglobulin G4 level: A single-center, retrospective cohort study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Guan-Zhou Zhou, Jia-Qi Zeng, Lei Wang, Miao Liu, Ke Meng, Zi-Kai Wang, Xiu-Li Zhang, Li-Hua Peng, Bin Yan and Fei Pan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Young Scholar Independent Innovation Science Fund of Chinese PLA General Hospital |
No. 22QNCZ020 |
| National Key Research and Development Program |
No. 2022YFC2504003 |
|
| Corresponding Author |
Fei Pan, MD, PhD, Associate Chief Physician, Associate Professor, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China. panfei@plagh.org |
| Key Words |
Autoimmune pancreatitis; Immunoglobulin G4; Clinical characteristics; Outcome; Relapse; Cohort study |
| Core Tip |
Our findings suggested that patients with a high immunoglobulin (Ig) G4 level had different clinical features including a more active immune system and higher relapse rate. Patients with normal IgG4 level still require attention because they have a high incidence of jaundice and pancreatic atrophy. Some factors were identified as risk factors for relapse, such as age > 55 years [hazard ratio (HR) 2.383; 95% confidence interval (CI) 1.056-5.378; P = 0.036], high IgG4 level [> 2 × upper limit of normal (ULN) (HR 3.583; 95% CI 1.218-10.545; P = 0.020) and high IgA level (> 1 × ULN) (HR 5.908; 95% CI 1.199-29.120; P = 0.029). |
| Publish Date |
2023-09-14 14:58 |
| Citation |
Zhou GZ, Zeng JQ, Wang L, Liu M, Meng K, Wang ZK, Zhang XL, Peng LH, Yan B, Pan F. Clinical characteristics and outcome of autoimmune pancreatitis based on serum immunoglobulin G4 level: A single-center, retrospective cohort study. World J Gastroenterol 2023; 29(35): 5125-5137 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i35/5125.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i35.5125 |
