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Articles Published Processes
9/20/2023 4:48:37 PM | Browse: 185 | Download: 880
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Received |
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2023-06-14 08:25 |
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Peer-Review Started |
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2023-06-14 08:25 |
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First Decision by Editorial Office Director |
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2023-06-21 09:10 |
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Return for Revision |
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2023-06-21 09:10 |
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Revised |
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2023-06-25 06:23 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2023-07-14 06:07 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2023-07-14 07:45 |
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Articles in Press |
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2023-07-14 07:45 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-08-01 00:39 |
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Publish the Manuscript Online |
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2023-09-20 16:48 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Prospective Study |
| Article Title |
Effect of polyene phosphatidylcholine/ursodeoxycholic acid/ademetionine on pregnancy outcomes in intrahepatic cholestasis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Rui Dong, Qian-Qian Chen, Meng-Ling Xue, Ling Wang, Qin Wu and Teng-Fei Luo |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Teng-Fei Luo, MD, Attending Doctor, Department of Obstetrics and Gynecology, Hangzhou Women's Hospital, No. 369 Kunpeng Road, Hangzhou 310016, Zhejiang Province, China. qiangzhuoxinliang@126.com |
| Key Words |
Ademetionine 1,4-butanedisulfonate; Bile acids; Intrahepatic cholestasis of pregnancy; Liver enzyme indices; Polyene phosphatidylcholine; Pregnancy outcome; Ursodeoxycholic acid |
| Core Tip |
Intrahepatic cholestasis of pregnancy (ICP) can have negative effects on pregnancy outcomes, but the standard treatment with ursodeoxycholic acid and ademetionine is not always effective. This study aimed to evaluate the use of polyene phosphatidylcholine in combination with ursodeoxycholic acid and ademetionine for ICP treatment. The study involved 600 patients with ICP who were randomly assigned to receive either the standard dual-drug combination or the triple-drug combination including polyene phosphatidylcholine. The outcomes measured included bile acid levels, liver enzyme indices, and pregnancy outcomes. The results showed that the triple-drug combination was more effective in reducing pruritus scores, bile acid levels, and liver enzyme indices in comparison to the dual-drug combination. Additionally, the triple-drug group had a lower incidence of adverse pregnancy outcomes. Therefore, it can be concluded that the use of polyene phosphatidylcholine/ursodeoxycholic acid/ademetionine 1,4-butanedisulfonate is a safe and effective treatment option for ICP, although further clinical trials are necessary to confirm its clinical application. |
| Publish Date |
2023-09-20 16:48 |
| Citation |
Dong XR, Chen QQ, Xue ML, Wang L, Wu Q, Luo TF. Effect of polyene phosphatidylcholine/ursodeoxycholic acid/ademetionine on pregnancy outcomes in intrahepatic cholestasis. World J Clin Cases 2023; 11(27): 6431-6439 |
| URL |
https://www.wjgnet.com/2307-8960/full/v11/i27/6431.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v11.i27.6431 |
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