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Articles Published Processes
9/20/2023 4:48:37 PM | Browse: 355 | Download: 1117
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Received |
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2023-06-01 14:30 |
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Peer-Review Started |
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2023-06-01 14:32 |
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First Decision by Editorial Office Director |
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2023-07-17 09:20 |
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Return for Revision |
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2023-07-17 09:20 |
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Revised |
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2023-07-30 04:11 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2023-08-18 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2023-08-18 09:09 |
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Articles in Press |
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2023-08-18 09:09 |
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Edit the Manuscript by Language Editor |
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2023-08-27 04:41 |
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Typeset the Manuscript |
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2023-09-12 06:07 |
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Publish the Manuscript Online |
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2023-09-20 16:48 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Case Report |
| Article Title |
Amniotic membrane mesenchymal stromal cell-derived secretome in the treatment of acute ischemic stroke: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fu-Hong Lin, Yu-Xiao Yang, Yu-Jun Wang, Suresh Kumar Subbiah and Xiao-Yun Wu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
81960252,81860157 |
| Natural Science Foundation of Inner Mongolia |
2021LHMS08019,2021LHMS08023 |
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| Corresponding Author |
Xiao-Yun Wu, PhD, Professor, Department of Technology, Research Center for Hua-Da Precision Medicine of Inner Mongolia Autonomous Region, No. 69 Horqin South Road, Hohhot 100000, Inner Mongolia Autonomous Region, China. stemcells@foxmail.com |
| Key Words |
Acute stroke; Amniotic membrane; Mesenchymal stromal cells; Extracellular vesicle; Clinical trial; Case report |
| Core Tip |
Mesenchymal stromal cells (MSCs) and their derivatives have been studied as a therapeutic alternative for stroke, and various preclinical have been reported. A 45-year-old female suffered an acute stroke, causing paralysis in the left upper and lower limbs. We transplanted the amniotic membrane MSCs-derived secretome (MSC-secretome) to the patient four times with a week interval. The clinical improvement of this patient was accompanied by an increased frequency of Tregs after transplantation. This study proves that intravenous transplantation of MSC-secretome potentially treats patients who suffer from acute ischemic stroke. |
| Publish Date |
2023-09-20 16:48 |
| Citation |
Lin FH, Yang YX, Wang YJ, Subbiah SK, Wu XY. Amniotic membrane mesenchymal stromal cell-derived secretome in the treatment of acute ischemic stroke: A case report. World J Clin Cases 2023; 11(27): 6543-6550 |
| URL |
https://www.wjgnet.com/2307-8960/full/v11/i27/6543.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v11.i27.6543 |
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