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Articles Published Processes
10/10/2023 8:15:35 AM | Browse: 475 | Download: 1355
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Received |
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2023-06-07 06:45 |
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Peer-Review Started |
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2023-06-05 06:38 |
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First Decision by Editorial Office Director |
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2023-07-08 08:50 |
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Return for Revision |
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2023-07-10 01:48 |
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Revised |
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2023-07-14 09:59 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2023-08-28 03:09 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2023-08-28 20:57 |
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Articles in Press |
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2023-08-28 20:57 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-09-04 05:58 |
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Publish the Manuscript Online |
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2023-10-10 08:15 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Case Report |
| Article Title |
Comprehensive next-generation sequencing reveals double primary colorectal carcinoma missed by diagnostic imaging: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Jun Qu, Qian-Shi Zhang, Bo Wang, Feng Zhang, Evenki Pan, Chun-Yan Zhao, Si-Ye Liu and Li-Ping Fang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Li-Ping Fang, MD, Professor, Department of Medical Oncolog, The Second Hospital of Dalian Medical University, No. 467 Zhongshan Road, Shahekou District, Dalian 116023, Liaoning Province, China. fangliping10000@dmu.edu.cn |
| Key Words |
Multiple primary colorectal carcinoma; Next-generation sequencing; Cetuximab; RET fusion; Case report |
| Core Tip |
We report a rare case of a 63-year-old male patient diagnosed with multiple primary colorectal carcinomas through targeted next-generation sequencing, which was initially missed by diagnostic imaging. The patient was found to have two tumors located on the colorectal surface which had different genomic alterations, as evidenced by immunohistochemistry staining. The patient benefited from treatment with the epidermal growth factor receptor inhibitor cetuximab due to the wild-type KRAS detected in the unresected tumor. This case emphasizes the importance of genetic testing for primary tumor diagnosis and the need for longitudinal circulating tumor DNA profiling to develop effective therapeutic strategies. |
| Publish Date |
2023-10-10 08:15 |
| Citation |
Qu YJ, Zhang QS, Wang B, Zhang F, Pan E, Zhao CY, Liu SY, Fang LP. Comprehensive next-generation sequencing reveals double primary colorectal carcinoma missed by diagnostic imaging: A case report. World J Gastrointest Oncol 2023; 15(10): 1823-1828
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| URL |
https://www.wjgnet.com/1948-5204/full/v15/i10/1823.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i10.1823 |
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