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Articles Published Processes
9/25/2023 11:20:42 AM | Browse: 154 | Download: 334
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Received |
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2023-07-06 09:02 |
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Peer-Review Started |
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2023-07-06 09:02 |
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To Make the First Decision |
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Return for Revision |
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2023-07-27 08:33 |
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Revised |
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2023-07-28 03:15 |
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Second Decision |
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2023-08-31 02:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-08-31 07:35 |
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Articles in Press |
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2023-08-31 07:35 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-09-20 00:56 |
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Publish the Manuscript Online |
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2023-09-25 11:20 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Retrospective Study |
| Article Title |
Clinical value of chemiluminescence method for detection of antinuclear antibody profiles
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hui-Yao Xiang, Xi-Ying Xiang, Ting-Bo Ten, Xie Ding, Yu-Wen Liu and Chun-Hua Luo |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Chun-Hua Luo, MD, Attending Doctor, Medical Laboratory Science, The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, No. 183 Yiling Avenue, Yichang 443003, Hubei Province, China. douxia833@126.com |
| Key Words |
Chemiluminescence assay; Immunoblotting; Antinuclear antibody profile; Autoimmune diseases; Systemic lupus erythematosus; Diagnostic model |
| Core Tip |
Antinuclear antibodies (ANAs) are important biomarkers for diagnosing autoimmune diseases, with systemic lupus erythematosus (SLE) being one of the most well-known. This study aimed to compare the performance of two commonly used ANA detection methods, chemiluminescence assay (CLIA) and line immunoassay, in patients with autoimmune diseases. The findings demonstrated that for ANAs, particularly those associated with SLE, both techniques had equivalent detection rates and diagnostic precision. Additionally, a diagnostic model for SLE that uses CLIA-detected antibodies has been developed and shown to have better diagnostic accuracy than individual antibodies. Specifically, a combination of anti-dsDNA antibodies and anti-Ro60 antibodies detected by CLIA provided an effective strategy for diagnosing SLE. These results imply that an adequate diagnosis of SLE may benefit from a diagnostic model based on CLIA-detected antibodies, ultimately resulting in more efficient management and treatment of this autoimmune disease. |
| Publish Date |
2023-09-25 11:20 |
| Citation |
Xiang HY, Xiang XY, Ten TB, Ding X, Liu YW, Luo CH. Clinical value of chemiluminescence method for detection of antinuclear antibody profiles. World J Clin Cases 2023; 11(28): 6688-6697 |
| URL |
https://www.wjgnet.com/2307-8960/full/v11/i28/6688.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v11.i28.6688 |
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