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Articles Published Processes
9/15/2023 10:42:35 AM | Browse: 209 | Download: 402
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Received |
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2023-06-17 19:44 |
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Peer-Review Started |
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2023-06-17 19:46 |
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To Make the First Decision |
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Return for Revision |
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2023-07-04 08:49 |
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Revised |
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2023-07-16 16:47 |
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Second Decision |
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2023-08-11 02:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-08-11 08:22 |
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Articles in Press |
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2023-08-11 08:22 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-09-08 15:07 |
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Publish the Manuscript Online |
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2023-09-15 10:42 |
| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Review |
| Article Title |
Neurologic orphan diseases: Emerging innovations and role for genetic treatments
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ivelina P Kioutchoukova, Devon T Foster, Rajvi N Thakkar, Marco A Foreman, Brandon J Burgess, Rebecca M Toms, Eduardo E Molina Valero and Brandon Lucke-Wold |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Brandon Lucke-Wold, MD, PhD, Neurosurgeon, Department of Neurosurgery, University of Florida, 1505 SW Archer Rd, Gainesville, FL 32611, United States. brandon.lucke-wold@neurosurgery.ufl.edu |
| Key Words |
Neurologic orphan diseases; gene therapy; Clustered regularly interspaced palindromic repeats/Cas9; Antisense oligonucleotides; Adeno-associated virus; mTOR inhibitors |
| Core Tip |
Neurologic orphan diseases are rare conditions that impact a small percentage of the population. Through new advances in technology and research, the use of genetic treatment for these conditions is increasing. Recent advances in clustered regularly interspaced palindromic repeats/Cas9, adeno-associated viral vectors, antisense oligonucleotides, and mammalian target of rapamycin inhibitors have shown improvements in the care of patients and their quality of life. |
| Publish Date |
2023-09-15 10:42 |
| Citation |
Kioutchoukova IP, Foster DT, Thakkar RN, Foreman MA, Burgess BJ, Toms RM, Molina Valero EE, Lucke-Wold B. Neurologic orphan diseases: Emerging innovations and role for genetic treatments. World J Exp Med 2023; 13(4): 59-74 |
| URL |
https://www.wjgnet.com/2220-315x/full/v13/i4/59.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v13.i4.59 |
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