Publication Name	World Journal of Clinical Cases
Manuscript ID	86436
Country	Brazil

Received	2023-06-18 22:14
Peer-Review Started	2023-06-18 22:18
To Make the First Decision
Return for Revision	2023-07-04 03:31
Revised	2023-07-05 00:04
Second Decision	2023-07-24 03:06
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-07-25 07:54
Articles in Press	2023-07-25 07:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-08-07 02:42
Publish the Manuscript Online	2023-08-25 08:26

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Case Report
Article Title	Fecal transplantation in patient with metastatic melanoma refractory to immunotherapy: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Auro del Giglio and Fabio Cesar Atui
ORCID	Author(s) ORCID Number Auro del Giglio http://orcid.org/0000-0002-2009-824X
Funding Agency and Grant Number
Corresponding Author	Auro del Giglio, MD, Professor, Department of Oncology, Faculdade de Medicina da Fundação ABC, Avenida Príncipe de Gales 821, Santo André 09060-870, São Paulo, Brazil. aurodelgiglio@gmail.com
Key Words	Melanoma; Fecal microbiota transplantation; Immunotherapy resistance; Metastatic melanoma; Gut microbiome; Cancer; Case report
Core Tip	This case report highlights the use of fecal microbiota transplantation (FMT) as a potential strategy to overcome immunotherapy resistance in metastatic melanoma patients. The case involves a 57-year-old male who had failed multiple lines of treatment and received FMT alongside anti-programmed death-ligand 1 immunotherapy. Following FMT, the patient showed a response with a decrease in disease burden and remained on immunotherapy more than two years. This suggests that FMT may restore sensitivity to immunotherapy in refractory cases. Further research is needed to understand the underlying mechanisms and optimize treatment protocols for FMT in metastatic melanoma.
Publish Date	2023-08-25 08:26
Citation	del Giglio A, Atui FC. Fecal transplantation in patient with metastatic melanoma refractory to immunotherapy: A case report. World J Clin Cases 2023; 11(24): 5830-5834
URL	https://www.wjgnet.com/2307-8960/full/v11/i24/5830.htm
DOI	https://dx.doi.org/10.12998/wjcc.v11.i24.5830

Full Article (PDF)	WJCC-11-5830-with-cover.pdf
Full Article (Word)	WJCC-11-5830.docx
CARE Checklist–2016	86436-CARE-Checklist–2016-revision.pdf
Manuscript File	86436_Auto_Edited-LJH-JLW.docx
Answering Reviewers	86436-Answering reviewers).pdf
Audio Core Tip	86436-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	86436-Conflict-of-interest statement.pdf
Copyright License Agreement	86436-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s)	86436-Informed consent statement.pdf
Peer-review Report	86436-Peer-review(s).pdf
Scientific Misconduct Check	86436-Bing-Liu JH-2.png
Scientific Misconduct Check	86436-CrossCheck.png
Scientific Editor Work List	86436-Scientific editor work list.pdf
CrossCheck Report	86436-CrossCheck report.pdf