Publication Name	World Journal of Gastroenterology
Manuscript ID	8646
Country	China

Received	2013-12-31 16:07
Peer-Review Started	2013-12-31 21:52
To Make the First Decision	2014-01-24 14:05
Return for Revision	2014-01-24 21:33
Revised	2014-02-09 23:06
Second Decision	2014-03-05 14:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-05 14:52
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-31 22:17
Typeset the Manuscript	2014-04-15 10:21
Publish the Manuscript Online	2014-04-29 09:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Physiology
Manuscript Type	Autobiography
Article Title	Localization and vasopressin regulation of the Na+-K+-2Cl- cotransporter in the distal colonic epithelium
Manuscript Source	Unsolicited Manuscript
All Author List	Hong Xue, Zi-Juan Zhang, Xiao-Shuang Li, Hai-Mei Sun, Qian Kang, Bo Wu, Ya-Xi Wang, Wan-Jing Zou and De-Shan Zhou
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 31271290 National Natural Science Foundation of China 31000514 Scientific Research Key Program of Beijing Municipal Commission of Education KZ201310025020 Beijing Postdoctoral Research Foundation Beijing Natural Science Foundation 7142025
Corresponding Author	De-Shan Zhou, MD, Department of Histology and Embryology, School of Basic Medical Sciences, Capital Medical University, Xitoutiao 10, Beijing 100069, China. zhouds08@ccmu.edu.cn
Key Words	Na+-K+-2Cl- cotransporter; Apical membrane; Vasopressin; Distal colonic epithelia; Trafficking
Core Tip	The Na+-K+-2Cl- cotransporter (NKCC2), which was thought to be only expressed in the apical membrane of the epithelial cells in the thick ascending limb of Henle’s loop, was recently found to be expressed in the colon. However, the role and regulating mechanism of NKCC2 in the gut are still not completely understood. Our results provide direct evidence that vasopressin also plays an important role in the colonic epithelia by stimulating NKCC2 trafficking to the apical membrane and inducing NKCC2-mediated ion transport. The action of vasopressin on NKCC2 in the colon would be recognized to supplement the role of the kidney in modulating whole-body homeostasis and electrolyte balance in physiological or pathophysiologic conditions.
Publish Date	2014-04-29 09:53
Citation	Xue H, Zhang ZJ, Li XS, Sun HM, Kang Q, Wu B, Wang YX, Zou WJ, Zhou DS. Localization and vasopressin regulation of the Na+-K+-2Cl- cotransporter in the distal colonic epithelium. World J Gastroenterol 2014; 20(16): 4692-4701
URL	http://www.wjgnet.com/1007-9327/full/v20/i16/4692.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i16.4692

Full Article (PDF)	WJG-20-4692.pdf
Full Article (Word)	WJG-20-4692.doc
Manuscript File	8646-Review.docx
Answering Reviewers	8646-Answering reviewers.pdf
Copyright License Agreement	8646-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	8646-Language certificate.pdf
Peer-review Report	8646-Peer review(s).pdf
Scientific Editor Work List	8646-Scientific editor work list.doc