Publication Name	World Journal of Clinical Oncology
Manuscript ID	8655
Country	Greece

Received	2014-01-02 09:15
Peer-Review Started	2014-01-02 15:18
To Make the First Decision	2014-03-12 16:54
Return for Revision	2014-03-20 20:18
Revised	2014-04-01 01:59
Second Decision	2014-10-10 18:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-10-10 18:14
Articles in Press	2014-10-10 18:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-19 11:03
Publish the Manuscript Online	2014-12-11 14:23

ISSN	2218-4333 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Association of survivin splice variants with prognosis and treatment of breast cancer
Manuscript Source	Invited Manuscript
All Author List	Anastasia Pavlidou, Christos Kroupis and Kleanthi Dimas
Funding Agency and Grant Number
Corresponding Author	Christos Kroupis, MSc, PhD, Assistant Professor, Department of Clinical Biochemistry, Attikon University General Hospital, Rimini 1, Haidari 12462, Greece. ckroupis@med.uoa.gr
Key Words	Survivin gene; Isoforms; Therapy; Prognosis; Breast cancer
Core Tip	Besides wild type survivin full length transcript, another six splice variants have been identified. Overexpression of survivin and its isoforms leads to shorter overall and disease-free survival; the transcript variants are positively correlated with apoptosis and could assist prognosis prediction. It has been proved through numerous studies that inhibiting survivin isoforms might become a promising target of drug therapy of carcinomas. Use of small molecule YM155 could offer new therapy for triple negative breast cancer patients while, chemotherapy with FEC and Tax-Epi could be guided by survivin splice variants measurements. Survivin transcript variants could become prognostic biomarkers and could provide information about clinical management of patients suffering from breast cancer.
Publish Date	2014-12-11 14:23
Citation	Pavlidou A, Kroupis C, Dimas K. Association of survivin splice variants with prognosis and treatment of breast cancer. World J Clin Oncol 2014; 5(5): 883-894
URL	http://www.wjgnet.com/2218-4333/full/v5/i5/883.htm
DOI	http://dx.doi.org/10.5306/wjco.v5.i5.883

Full Article (PDF)	WJCO-5-883.pdf
Full Article (Word)	WJCO-5-883.doc
Manuscript File	8655-Review.doc
Answering Reviewers	8655-Answering reviewers.pdf
Copyright License Agreement	8655-Copyright assignment.pdf
Peer-review Report	8655-Peer review(s).pdf
Scientific Misconduct Check	8655-CrossCheck.jpg
Scientific Editor Work List	8655-Scientific editor work list.pdf