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Articles Published Processes
12/11/2014 2:06:00 PM | Browse: 1230 | Download: 1615
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Received |
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2014-01-02 09:15 |
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Peer-Review Started |
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2014-01-02 15:18 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-03-20 20:18 |
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Revised |
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2014-04-01 01:59 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-10-10 18:01 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-10-10 18:14 |
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Articles in Press |
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2014-10-10 18:14 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-11-19 11:03 |
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Publish the Manuscript Online |
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2014-12-11 14:23 |
| Category |
Oncology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Association of survivin splice variants with prognosis and treatment of breast cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Anastasia Pavlidou, Christos Kroupis and Kleanthi Dimas |
| Funding Agency and Grant Number |
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| Corresponding Author |
Christos Kroupis, MSc, PhD, Assistant Professor, Department of Clinical Biochemistry, Attikon University General Hospital, Rimini 1, Haidari 12462, Greece. ckroupis@med.uoa.gr |
| Key Words |
Survivin gene; Isoforms; Therapy; Prognosis; Breast cancer |
| Core Tip |
Besides wild type survivin full length transcript, another six splice variants have been identified. Overexpression of survivin and its isoforms leads to shorter overall and disease-free survival; the transcript variants are positively correlated with apoptosis and could assist prognosis prediction. It has been proved through numerous studies that inhibiting survivin isoforms might become a promising target of drug therapy of carcinomas. Use of small molecule YM155 could offer new therapy for triple negative breast cancer patients while, chemotherapy with FEC and Tax-Epi could be guided by survivin splice variants measurements. Survivin transcript variants could become prognostic biomarkers and could provide information about clinical management of patients suffering from breast cancer. |
| Publish Date |
2014-12-11 14:23 |
| Citation |
Pavlidou A, Kroupis C, Dimas K. Association of survivin splice variants with prognosis and treatment of breast cancer. World J Clin Oncol 2014; 5(5): 883-894 |
| URL |
http://www.wjgnet.com/2218-4333/full/v5/i5/883.htm |
| DOI |
http://dx.doi.org/10.5306/wjco.v5.i5.883 |
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