| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Expression characteristics of peripheral lymphocyte programmed death 1 and FoxP3+ Tregs in gastric cancer during surgery and chemotherapy
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hao Li, Guan-Mei Cao, Guo-Li Gu, Song-Yan Li, Yang Yan, Ze Fu and Xiao-Hui Du |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
81871317 |
| Military Medical Innovation Project |
18cxz025 |
|
| Corresponding Author |
Xiao-Hui Du, MD, PhD, Chief Doctor, Deputy Director, Professor, Surgeon, Department of General Surgery, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100039, China. duxiaohui3011@sina.com |
| Key Words |
Programmed death 1; Active regulatory T cells; Stomach cancer; Peripheral lymphocyte |
| Core Tip |
In short, this paper shows that programmed death 1 (PD-1) expression on immune subsets and the number of FoxP3+ Treg were higher in peripheral blood of patients with gastric cancer than healthy donors. PD-1 expression and the number of FoxP3+ Treg decrease notably after D2 gastrectomy. PD-1 expression declines on lymphocytes, CD8+, CD45RO+ and CD8+CD45RO+ populations during postoperative chemotherapy. PD-1 expression correlates with the number of CD4+CD45RO+FoxP3 high activated Treg in peripheral lymphocytes. This paper is particularly timely, as the studies of PD-1 expression on immune subsets in peripheral blood are of expanding interest. As well as providing some novel insight for future studies of tumor recurrence and tumor immune escape, our results might also be a reference to determining the timing and dose of clinical anti-PD-1 antibodies, and we anticipate that this study will be widely cited. |
| Publish Date |
2023-10-27 15:28 |
| Citation |
Li H, Cao GM, Gu GL, Li SY, Yan Y, Fu Z, Du XH. Expression characteristics of peripheral lymphocyte programmed death 1 and FoxP3+ Tregs in gastric cancer during surgery and chemotherapy. World J Gastroenterol 2023; 29(40): 5582-5592 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i40/5582.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i40.5582 |
