Publication Name	World Journal of Cardiology
Manuscript ID	8705
Country	United States

Received	2014-01-03 15:53
Peer-Review Started	2014-01-03 21:00
First Decision by Editorial Office Director
Return for Revision	2014-03-20 20:20
Revised	2014-04-29 23:08
Publication Fee Transferred
Second Decision by Editor	2014-06-27 17:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-06-27 17:48
Articles in Press	2014-06-27 18:10
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-28 13:58
Publish the Manuscript Online	2014-09-17 14:32

ISSN	1949-8462 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biology
Manuscript Type	Topic Highlights
Article Title	Pulmonary hypertension and metabolic syndrome: Possible connection, PPARγ and Caveolin-1
Manuscript Source	Invited Manuscript
All Author List	Rajamma Mathew
Funding Agency and Grant Number
Corresponding Author	Rajamma Mathew, MD, Department of Physiology, New York Medical College, Valhalla, Basic Science Building, Rm #A11, Valhalla, NY10595, United States. rajamma_mathew@nymc.edu
Key Words	Adiponectin; Caveolin-1; Leptin; Metabolic Syndrome; Pulmonary hypertension; Peroxisome proliferator-activated receptor
Core Tip	Pulmonary hypertension (PH) is a devastating disease with a high morbidity and mortality rate. Recent studies indicate that the metabolic alterations that occur during the course of PH have a negative effect. Importantly, PH has been observed in patients with metabolic syndrome. Caveolin-1, a membrane protein and peroxisome proliferator-activated receptor γ, a ligand activated transcription factor are abundantly expressed in vascular cells and adipocytes. They play a significant role in maintaining vascular health, and participate in glucose and lipid metabolism. Furthermore, the proximity of vasculature and adipose tissue facilitates reciprocal influence during health and disease.
Publish Date	2014-09-17 14:32
Citation	Mathew R. Pulmonary hypertension and metabolic syndrome: Possible connection, PPARγ and Caveolin-1. World J Cardiol 2014; 6(8): 692-705
URL	http://www.wjgnet.com/1949-8462/full/v6/i8/692.htm
DOI	http://dx.doi.org/10.4330/wjc.v6.i8.692

Full Article (PDF)	WJC-6-692.pdf
Full Article (Word)	WJC-6-692.doc
Manuscript File	8705-Review.doc
Answering Reviewers	8705-Answering reviewers.pdf
Copyright License Agreement	8705-Copyright assignment.pdf
Peer-review Report	8705-Peer review(s).pdf
Scientific Misconduct Check	8705-CrossCheck.jpg
Scientific Editor Work List	8705-Scientific editor work list.pdf