Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	87122
Country	China

Received	2023-09-05 08:34
Peer-Review Started	2023-09-05 08:34
First Decision by Editorial Office Director	2023-09-15 22:51
Return for Revision	2023-09-15 22:51
Revised	2023-10-09 03:34
Publication Fee Transferred
Second Decision by Editor	2023-11-01 07:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2023-11-08 21:40
Articles in Press	2023-11-08 21:40
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-12-06 14:55
Publish the Manuscript Online	2023-12-14 05:08

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Immunology
Manuscript Type	Basic Study
Article Title	Combined TIM-3 and PD-1 blockade restrains hepatocellular carcinoma development by facilitating CD4+ and CD8+ T cell-mediated antitumor immune responses
Manuscript Source	Unsolicited Manuscript
All Author List	Xu-Sheng Zhang, Hong-Cai Zhou, Peng Wei, Long Chen, Wei-Hu Ma, Lin Ding, Shi-Cai Liang and Ben-Dong Chen
ORCID	Author(s) ORCID Number Ben-Dong Chen http://orcid.org/0009-0007-9960-1146
Funding Agency and Grant Number	Funding Agency Grant Number First-Class Discipline Construction Founded Project of Ningxia Medical University and the School of Clinical Medicine 2020008
Corresponding Author	Ben-Dong Chen, MD, Doctor, Doctor, Department of Hepatobiliary Surgery, The General Hospital of Ningxia Medical University, No. 804 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China. bendong8511@nyfy.com.cn
Key Words	Hepatocellular carcinoma; T cell immunoglobulin and mucin domain-containing protein 3; Programmed cell death protein 1; CD4+ T cells; CD8+ T cells
Core Tip	This study investigated the effects of combined blockade of T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) and programmed cell death protein 1 (PD-1) on tumor development in a hepatocellular carcinoma (HCC) mouse model. We showed that combined TIM-3 and PD-1 blockade had more substantial inhibitory effects on tumor growth in mice compared with individual blockade. The combined therapy increased T cell infiltration and ameliorated CD4+ and CD8+ T cell exhaustion in HCC mouse model. Our findings proposed an effective immunotherapy and may provide more treatment options for HCC patients.
Publish Date	2023-12-14 05:08
Citation	Zhang XS, Zhou HC, Wei P, Chen L, Ma WH, Ding L, Liang SC, Chen BD. Combined TIM-3 and PD-1 blockade restrains hepatocellular carcinoma development by facilitating CD4+ and CD8+ T cell-mediated antitumor immune responses. World J Gastrointest Oncol 2023; 15(12): 2138-2149
URL	https://www.wjgnet.com/1948-5204/full/v15/i12/2138.htm
DOI	https://dx.doi.org/10.4251/wjgo.v15.i12.2138

Full Article (PDF)	WJGO-15-2138-with-cover.pdf
Full Article (Word)	WJGO-15-2138.docx
The ARRIVE Guidelines	87122-The ARRIVE guidelines.pdf
Manuscript File	87122_Auto_Edited-LM.docx
Answering Reviewers	87122-Answering reviewers.pdf
Audio Core Tip	87122-Audio core tip.mp3
Biostatistics Review Certificate	87122-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	87122-Conflict-of-interest statement.pdf
Copyright License Agreement	87122-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	87122-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	87122-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	87122-Language certificate.pdf
Peer-review Report	87122-Peer-review(s).pdf
Scientific Misconduct Check	87122-Bing-Wang JJ-2.png
Scientific Editor Work List	87122-Scientific editor work list.pdf
CrossCheck Report	87122-CrossCheck report.pdf