| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Mechanism of pachymic acid in the treatment of gastric cancer based on network pharmacology and experimental verification
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu-Hua Du, Jian-Jun Zhao, Xia Li, Shi-Cong Huang, Na Ning, Guo-Qing Chen, Yi Yang, Yi Nan and Ling Yuan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ningxia Science and Technology Benefiting People Program |
2022CMG03064 |
| National Natural Science Foundation of China |
82260879 |
| Ningxia Natural Science Foundation |
2022AAC03144, 2022AAC02039 |
|
| Corresponding Author |
Ling Yuan, PhD, Professor, College of Pharmacy, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China. 20080017@nxmu.edu.cn |
| Key Words |
Pachymic acid; Gastric cancer; Network pharmacology; Enrichment analysis; Cell proliferation |
| Core Tip |
Pachymic acid (PA) is an important bioactive component of Poria cocos. Network pharmacology analysis showed that the core targets of PA in treating gastric cancer (GC) were proto-oncogene tyrosine-protein kinase Src, mitogen-activated protein kinase 1, phosphatidylinositol 3-kinase regulatory subunit alpha, heat shock protein 90-alpha, and tyrosine-protein phosphatase non-receptor type 11. Molecular docking results showed that PA could combine well with the core targets. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and gene set enrichment analysis suggested that the PI3K-AKT signaling pathway was possible for treating GC with PA. The experiment results demonstrated that PA could decrease the survival rate of HGC-27 cells, halt the progression of the cell cycle, enhance cell apoptosis, control the PI3K/AKT signaling pathway to stimulate apoptosis, and impede cell growth. |
| Publish Date |
2024-01-11 06:17 |
| Citation |
Du YH, Zhao JJ, Li X, Huang SC, Ning N, Chen GQ, Yang Y, Nan Y, Yuan L. Mechanism of pachymic acid in the treatment of gastric cancer based on network pharmacology and experimental verification. World J Gastrointest Oncol 2024; 16(1): 30-50 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i1/30.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i1.30 |
