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Articles Published Processes
12/14/2023 5:08:46 AM | Browse: 108 | Download: 398
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Received |
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2023-07-29 04:29 |
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Peer-Review Started |
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2023-07-29 04:31 |
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To Make the First Decision |
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Return for Revision |
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2023-09-24 03:57 |
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Revised |
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2023-10-01 01:30 |
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Second Decision |
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2023-10-27 01:59 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-10-30 07:35 |
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Articles in Press |
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2023-10-30 07:35 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-12-04 03:35 |
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Publish the Manuscript Online |
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2023-12-14 05:08 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Evaluating the causal relationship between human blood metabolites and gastroesophageal reflux disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jia-Yan Hu, Mi Lv, Kun-Li Zhang, Xi-Yun Qiao, Yu-Xi Wang and Feng-Yun Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82174363 |
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| Corresponding Author |
Feng-Yun Wang, PhD, Chief Doctor, Professor, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Institute of Digestive Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, No. 1 Courtyard, Xiyuan Playground, Haidian District, Beijing 100091, China. wfy811@163.com |
| Key Words |
Blood metabolites; Gastroesophageal reflux disease; Mendelian randomization; Causality; Pathogenesis; Biomarkers; Metabolic pathway |
| Core Tip |
At present, there is no study on blood metabolomics of gastroesophageal reflux disease (GERD). This may be the first study combining metabolomics and genomics to explore the causal relationship between serum metabolites and GERD. We found that there was a significant correlation between eight metabolites and GERD, among which butyrylcarnitine was the most reliable pathogenic metabolite (odd ratio 1.10, 95% confidence interval: 1.05-1.16). Glycerophospholipid metabolism may be involved in the pathogenesis of GERD. The results provide a reference direction for the early screening, prevention and treatment of GERD and the design of future clinical research. |
| Publish Date |
2023-12-14 05:08 |
| Citation |
Hu JY, Lv M, Zhang KL, Qiao XY, Wang YX, Wang FY. Evaluating the causal relationship between human blood metabolites and gastroesophageal reflux disease. World J Gastrointest Oncol 2023; 15(12): 2169-2184 |
| URL |
https://www.wjgnet.com/1948-5204/full/v15/i12/2169.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i12.2169 |
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