Publication Name	World Journal of Experimental Medicine
Manuscript ID	87256
Country	Germany

Received	2023-09-13 16:40
Peer-Review Started	2023-09-13 16:40
To Make the First Decision
Return for Revision	2023-11-21 08:06
Revised	2023-11-30 20:27
Second Decision	2023-12-22 03:22
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-12-29 07:26
Articles in Press	2023-12-29 07:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-14 08:15
Publish the Manuscript Online	2024-03-19 14:54

ISSN	2220-315x (online)
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Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Effects of unilateral superimposed high-frequency jet ventilation on porcine hemodynamics and gas exchange during one-lung flooding
Manuscript Source	Unsolicited Manuscript
All Author List	Thomas Lesser, Frank Wolfram, Conny Braun and Reiner Gottschall
ORCID	Author(s) ORCID Number Thomas Lesser http://orcid.org/0000-0001-7543-0193
Funding Agency and Grant Number
Corresponding Author	Thomas Lesser, MD, Adjunct Professor, Department of thoracic and vascular surgery, SRH Wald Klinikum Gera, No. 122 Street of Peace, Gera D-07548, Germany. thomas.lesser@srh.de
Key Words	One-lung ventilation; Unilateral superimposed high-frequency jet ventilation; One-lung flooding
Core Tip	Lung cancer prognosis is among the most unfavourable of all cancers. Therefore, there is a need to improve local lung cancer therapy while avoiding surgery. One-lung flooding (OLF) involves unilateral lung filling with saline, which generates a suitable acoustic pathway for the transthoracic application of High-intensity focused ultrasound (HIFU) in the lung. Breathing and lung movement during HIFU procedures can result in incomplete tumor ablation or collateral damage. Superimposed high-frequency jet ventilation (SHFJV) can reduce respiratory motion. However, it is unclear whether unilateral SHFJV allows adequate haemodynamics and gas exchange. In this porcine model, unilateral SHFJV may provide adequate ventilation to animals in different positions during OLF. Lower oxygenation and carbon dioxide removal rates compared to pressure controlled ventilation did not lead to hypoxia or hypercapnia. SHFJV can safely minimise ventilation-induced lung motion during lung tumor ablation.
Publish Date	2024-03-19 14:54
Citation	Lesser T, Wolfram F, Braun C, Gottschall R. Effects of unilateral superimposed high-frequency jet ventilation on porcine hemodynamics and gas exchange during one-lung flooding. World J Exp Med 2024; 14(1): 87256
URL	https://www.wjgnet.com/2220-315x/full/v14/i1/87256.htm
DOI	https://dx.doi.org/10.5493/wjem.v14.i1.87256

Full Article (PDF)	WJEM-14-87256-with-cover.pdf
The ARRIVE Guidelines	87256-The ARRIVE guidelines.pdf
Manuscript File	87256_Auto_Edited-YJP.docx
Answering Reviewers	87256-Answering reviewers.pdf
Audio Core Tip	87256-Audio core tip.mp3
Biostatistics Review Certificate	87256-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	87256-Conflict-of-interest statement.pdf
Copyright License Agreement	87256-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	87256-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	87256-Language certificate.pdf
Peer-review Report	87256-Peer-review(s).pdf
Scientific Misconduct Check	87256-Bing-Qu XL-2.jpg
Scientific Editor Work List	87256-Scientific editor work list.pdf
CrossCheck Report	87256-CrossCheck report.pdf