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Articles Published Processes
10/27/2023 3:28:49 PM | Browse: 220 | Download: 913
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Received |
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2023-08-14 06:03 |
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Peer-Review Started |
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2023-08-14 06:06 |
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To Make the First Decision |
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Return for Revision |
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2023-09-19 06:11 |
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Revised |
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2023-10-04 11:52 |
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Second Decision |
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2023-10-13 01:56 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-10-23 06:44 |
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Articles in Press |
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2023-10-23 06:44 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-10-25 04:14 |
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Publish the Manuscript Online |
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2023-10-27 15:28 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Clinical significance of programmed cell death-ligand expression in small bowel adenocarcinoma is determined by the tumor microenvironment
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Aitoshi Hoshimoto, Atsushi Tatsuguchi, Ryohei Hamakubo, Takayoshi Nishimoto, Jun Omori, Naohiko Akimoto, Shu Tanaka, Shunji Fujimori, Tsutomu Hatori, Akira Shimizu and Katsuhiko Iwakiri |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Atsushi Tatsuguchi, MD, PhD, Associate Professor, Department of Gastroenterology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. tachan@nms.ac.jp |
| Key Words |
Small bowel adenocarcinoma; Programmed cell death-ligand 1; Programmed cell death-ligand 2; Tumor microenvironment; Tumor-infiltrating lymphocytes; Regulatory T-cells |
| Core Tip |
We investigated the clinicopathological significance of programmed cell death-ligand 1 (PD-L1) and programmed cell death-ligand 2 (PD-L2) expression in association with the infiltration of FoxP3+ and CD8+ T cells into the tumor microenvironment (TME) to identify PD-L/PD-1 immunotherapy candidates among patients with small bowel adenocarcinoma (SBA). We demonstrated that the status of the TME affects the clinical significance of PD-L1 and PD-L2. PD-L2 may be associated with poor prognosis of SBA patients with a high immune cell infiltration. |
| Publish Date |
2023-10-27 15:28 |
| Citation |
Hoshimoto A, Tatsuguchi A, Hamakubo R, Nishimoto T, Omori J, Akimoto N, Tanaka S, Fujimori S, Hatori T, Shimizu A, Iwakiri K. Clinical significance of programmed cell death-ligand expression in small bowel adenocarcinoma is determined by the tumor microenvironment. World J Gastroenterol 2023; 29(40): 5566-5581 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i40/5566.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i40.5566 |
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