| Category |
Transplantation |
| Manuscript Type |
Observational Study |
| Article Title |
Pro-atherosclerotic markers and cardiovascular risk factors one year after liver transplantation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Mario Reis Alvares-da-Silva, Claudia Pinto Marques Souza de Oliveira, José Tadeu Stefano, Hermes V Barbeiro, Denise Barbeiro, Francisco G Soriano, Alberto Queiroz Farias, Flair José Carrilho and Luiz Augusto Carneiro D’Albuquerque |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Department of Gastroenterology, School of Medicine, University of São Paulo, Brazil |
LIM-37/LIM07 |
|
| Corresponding Author |
Mario Reis Alvares-da-Silva, MD, PhD, Division of Gastroenterology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcellos, 2350, sala 2033, 90035-903 Porto Alegre, Brazil. marioreis@live.com |
| Key Words |
Cell adhesion molecules; Endothelial biomarkers; Cardiovascular disease; Nonalcoholic steatohepatitis; Metabolic syndrome |
| Core Tip |
Liver transplant (LT) patients a have high risk of long-term development of cardiovascular disease (CVD), which is currently recognized as an important cause of death 5 to 10 years after transplant in this population. Atherosclerosis is a hallmark of CVD, with both disorders involving a prolonged asymptomatic phase and often leading to morbidity and mortality upon initial clinical presentation. Regardless, endothelial dysfunction is the first step in developing early atherosclerosis. In the present study, we evaluated inflammatory and endothelial markers one year after transplantation in asymptomatic LT recipients in comparison to high-CVD-risk biopsy-proven nonalcoholic steatohepatitis (NASH) patients and healthy controls. We found that LT recipients had pro-inflammatory profiles and endothelial dysfunction similar to those of NASH patients, both of which were higher than those in the compared controls. These findings suggest that LT recipients, even in a short 1-year follow-up period, display a high atherosclerotic risk and should be carefully monitored to effectively prevent CVD. |
| Publish Date |
2014-07-14 17:39 |
| Citation |
Alvares-da-Silva MR, Oliveira CPMS, Stefano JT, Barbeiro HV, Barbeiro D, Soriano FG, Farias AQ, Carrilho FJ, Carneiro D’Albuquerque LA. Pro-atherosclerotic markers and cardiovascular risk factors one year after liver transplantation. World J Gastroenterol 2014; 20(26): 8667-8673 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i26/8667.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i26.8667 |
