Publication Name	World Journal of Gastroenterology
Manuscript ID	8730
Country	Brazil

Received	2014-01-08 18:32
Peer-Review Started	2014-01-10 08:23
First Decision by Editorial Office Director
Return for Revision	2014-02-18 21:25
Revised	2014-03-18 08:20
Publication Fee Transferred
Second Decision by Editor	2014-04-16 11:33
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-04-16 11:44
Articles in Press	2014-05-23 09:42
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-29 19:25
Publish the Manuscript Online	2014-07-14 17:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Transplantation
Manuscript Type	Observational Study
Article Title	Pro-atherosclerotic markers and cardiovascular risk factors one year after liver transplantation
Manuscript Source	Unsolicited Manuscript
All Author List	Mario Reis Alvares-da-Silva, Claudia Pinto Marques Souza de Oliveira, José Tadeu Stefano, Hermes V Barbeiro, Denise Barbeiro, Francisco G Soriano, Alberto Queiroz Farias, Flair José Carrilho and Luiz Augusto Carneiro D’Albuquerque
Funding Agency and Grant Number	Funding Agency Grant Number Department of Gastroenterology, School of Medicine, University of São Paulo, Brazil LIM-37/LIM07
Corresponding Author	Mario Reis Alvares-da-Silva, MD, PhD, Division of Gastroenterology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcellos, 2350, sala 2033, 90035-903 Porto Alegre, Brazil. marioreis@live.com
Key Words	Cell adhesion molecules; Endothelial biomarkers; Cardiovascular disease; Nonalcoholic steatohepatitis; Metabolic syndrome
Core Tip	Liver transplant (LT) patients a have high risk of long-term development of cardiovascular disease (CVD), which is currently recognized as an important cause of death 5 to 10 years after transplant in this population. Atherosclerosis is a hallmark of CVD, with both disorders involving a prolonged asymptomatic phase and often leading to morbidity and mortality upon initial clinical presentation. Regardless, endothelial dysfunction is the first step in developing early atherosclerosis. In the present study, we evaluated inflammatory and endothelial markers one year after transplantation in asymptomatic LT recipients in comparison to high-CVD-risk biopsy-proven nonalcoholic steatohepatitis (NASH) patients and healthy controls. We found that LT recipients had pro-inflammatory profiles and endothelial dysfunction similar to those of NASH patients, both of which were higher than those in the compared controls. These findings suggest that LT recipients, even in a short 1-year follow-up period, display a high atherosclerotic risk and should be carefully monitored to effectively prevent CVD.
Publish Date	2014-07-14 17:39
Citation	Alvares-da-Silva MR, Oliveira CPMS, Stefano JT, Barbeiro HV, Barbeiro D, Soriano FG, Farias AQ, Carrilho FJ, Carneiro D’Albuquerque LA. Pro-atherosclerotic markers and cardiovascular risk factors one year after liver transplantation. World J Gastroenterol 2014; 20(26): 8667-8673
URL	http://www.wjgnet.com/1007-9327/full/v20/i26/8667.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i26.8667

Full Article (PDF)	WJG-20-8667.pdf
Full Article (Word)	WJG-20-8667.doc
Manuscript File	8730-Review.docx
Answering Reviewers	8730-Answering reviewers.pdf
Copyright License Agreement	8730-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	8730-Language certificate.pdf
Peer-review Report	8730-Peer review.pdf
Scientific Editor Work List	8730-Scientific editor work list.doc