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Articles Published Processes
11/24/2023 4:14:42 AM | Browse: 199 | Download: 550
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Received |
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2023-08-15 06:58 |
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Peer-Review Started |
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2023-08-15 07:00 |
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To Make the First Decision |
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Return for Revision |
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2023-09-05 20:41 |
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Revised |
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2023-09-28 08:54 |
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Second Decision |
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2023-10-26 00:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-10-30 07:38 |
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Articles in Press |
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2023-10-30 07:38 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-11-09 00:08 |
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Typeset the Manuscript |
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2023-11-21 09:58 |
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Publish the Manuscript Online |
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2023-11-24 04:14 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Hypoxia and inflammatory factor preconditioning enhances the immunosuppressive properties of human umbilical cord mesenchymal stem cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hang Li, Xiao-Qing Ji, Shu-Ming Zhang and Ri-Hui Bi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
31200899 |
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| Corresponding Author |
Ri-Hui Bi, Doctor, Surgeon, Department of Hepatobiliary Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Hospital Affiliated to Shanxi Medical University, The Third Hospital of Shanxi Medical University, No. 99 Longcheng, Xiaodian District, Taiyuan 030002, Shanxi Province, China. birihui@sxmu.edu.cn |
| Key Words |
Mesenchymal stem cells; Umbilical cord; Preconditioning; Hypoxia, Inflammatory factors; Immune regulation |
| Core Tip |
Mesenchymal stem cells (MSCs) are potential candidates for treating many immune diseases due to their unique immunomodulatory abilities, but a low survival rate and weakened function after venous transplantation reduces their treatment potential. Therefore, our study reveals a combination pretreatment method based on hypoxia exposure and inflammatory factor treatment in vitro that simulates the harsh in vivo environment to protect MSCs from injury after intravenous transfusion and promote high immunosuppressive effects of MSCs. |
| Publish Date |
2023-11-24 04:14 |
| Citation |
Li H, Ji XQ, Zhang SM, Bi RH. Hypoxia and inflammatory factor preconditioning enhances the immunosuppressive properties of human umbilical cord mesenchymal stem cells. World J Stem Cells 2023; 15(11): 999-1016 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i11/999.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i11.999 |
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